Li Bo, Wang Xiao-Li
Pediatric Surgery of Second People's Hospital of Liaocheng City, Linqing, Shandong 252600, P.R. China.
Mol Med Rep. 2016 Dec;14(6):5357-5362. doi: 10.3892/mmr.2016.5903. Epub 2016 Oct 31.
Polydatin is a natural extract used in traditional Chinese medicine, which leads to a marked improvement in the microcirculation perfusion and enhances the animal myocardial contraction force. The present study aimed to determine whether an effective treatment of polydatin ameliorates the symptoms of collagen‑induced arthritis (CIA), and also to explore the potential mechanism. Male DBA/1J mice were induced into CIA model mice. The administration of polydatin effectively suppressed CIA in mice. The serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor‑α (TNF‑α) and interleukin 1β (IL‑1β) were effectively increased following the induction of CIA in the model mice compared with the control group. The elevated serum levels of MDA, SOD, TNF‑α and IL‑1β were markedly suppressed by the effective treatment of polydatin in CIA mice, compared with the CIA model group. However, an increase in the level of matrix metalloproteinase‑9 (MMP‑9) was markedly induced in the CIA mice compared with the control group. As compared with the CIA group, the expression of MMP‑9 was substantially reduced by the effective treatment of polydatin. Taken together, the effective treatment of polydatin ameliorated the symptoms of CIA through an exertion of its antioxidative and anti‑inflammatory effects, and also via activation of the expression of matrix metalloproteinase-9 (MMP-9) in mice.
虎杖苷是一种用于传统中药的天然提取物，可显著改善微循环灌注并增强动物心肌收缩力。本研究旨在确定虎杖苷的有效治疗是否能改善胶原诱导性关节炎（CIA）的症状，并探索其潜在机制。将雄性DBA/1J小鼠诱导成CIA模型小鼠。虎杖苷给药有效抑制了小鼠的CIA。与对照组相比，模型小鼠诱导CIA后，血清丙二醛（MDA）、超氧化物歧化酶（SOD）、肿瘤坏死因子-α（TNF-α）和白细胞介素1β（IL-1β）水平有效升高。与CIA模型组相比，虎杖苷有效治疗显著抑制了CIA小鼠血清中升高的MDA、SOD、TNF-α和IL-1β水平。然而，与对照组相比，CIA小鼠中基质金属蛋白酶-9（MMP-9）水平显著升高。与CIA组相比，虎杖苷有效治疗使MMP-9的表达大幅降低。综上所述，虎杖苷的有效治疗通过发挥其抗氧化和抗炎作用，以及激活小鼠基质金属蛋白酶-9（MMP-9）的表达，改善了CIA的症状。
