Narenmandula Buren, Zhou Xiaojun, Li Youcheng, Tu Dongpei, Bao Yixin, Zheng Rongyuan, Xu Huiqin
Neurology Division One, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Radiology Imaging Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Neurol India. 2016 Nov-Dec;64(6):1233-1242. doi: 10.4103/0028-3886.193839.
This study was conducted to investigate the associations between white matter lesions and language and memory dysfunctions in patients with magnetic resonance imaging (MRI)-negative temporal lobe epilepsy.
This study included 26 patients with temporal lobe epilepsy, who did not have significant findings on conventional MRI scanning, and 17 healthy subjects as control. Diffusion tensor imaging data was obtained with a 3Tesla (T) MRI scanner. Neuropsychological scores of language and memory functions were measured. One-way analysis of variance was used to analyze abnormal fractional anisotropy and mean diffusivity values. Correlations were performed to evaluate the relationship between fractional anisotropy/mean diffusivity of each fiber tract and neuropsychological measures. Regression analysis was performed to determine the contribution of each fiber tract to cognitive performance.
Our data showed significantly decreased neuropsychological scores in the left and right temporal lobe epilepsy groups compared with control; it however, failed to show a statistical difference between the two groups. For the left temporal lobe epilepsy group, the mean diffusivity of the left parahippocampal and cingulate cortex, right arcuate fasciculus, and left fornix were significantly higher than control. Fractional anisotropy of the right fornix and mean diffusivity of the left uncinate fasciculus were significantly related to confrontational naming scores. There were significant correlations between the fractional anisotropy of the left fornix and verbal delayed memory scores and between the fractional anisotropy of the left fornix and nonverbal delayed memory scores. The mean diffusivity of left fractional anisotropy and the fractional anisotropy of the left uncinate fasciculus were significantly related to confrontational naming and verbal fluency scores, and seizure frequency was significantly related to nonverbal delayed memory scores.
Language and memory function impairment was correlated with white matter structural integrity.
本研究旨在调查磁共振成像（MRI）阴性的颞叶癫痫患者白质病变与语言和记忆功能障碍之间的关联。
本研究纳入26例颞叶癫痫患者，这些患者在传统MRI扫描中未发现显著异常，以及17名健康受试者作为对照。使用3特斯拉（T）MRI扫描仪获取扩散张量成像数据。测量语言和记忆功能的神经心理学评分。采用单因素方差分析来分析异常的各向异性分数和平均扩散率值。进行相关性分析以评估各纤维束的各向异性分数/平均扩散率与神经心理学测量之间的关系。进行回归分析以确定各纤维束对认知表现的贡献。
我们的数据显示，与对照组相比，左、右颞叶癫痫组的神经心理学评分显著降低；然而，两组之间未显示出统计学差异。对于左颞叶癫痫组，左侧海马旁回和扣带回皮质、右侧弓状束以及左侧穹窿的平均扩散率显著高于对照组。右侧穹窿的各向异性分数和左侧钩束的平均扩散率与对面对称命名评分显著相关。左侧穹窿的各向异性分数与言语延迟记忆评分之间以及左侧穹窿的各向异性分数与非言语延迟记忆评分之间存在显著相关性。左侧各向异性分数的平均扩散率和左侧钩束的各向异性分数与对面对称命名和言语流畅性评分显著相关，癫痫发作频率与非言语延迟记忆评分显著相关。
语言和记忆功能障碍与白质结构完整性相关。
