Liu Jun, Fan Peishi, Chu Jun, Yang Jian, Yang Xiaohu, Zhang Lu, Guo Chunliang
Department of Hepatobiliary Surgery, Affiliated Hospital of the Logistical College of Chinese People's Armed Police Forces, Tianjin, China.
Department of Hepatobiliary Surgery, Affiliated Hospital of the Logistical College of Chinese People's Armed Police Forces, Tianjin, China -
Minerva Chir. 2017 Apr;72(2):121-124. doi: 10.23736/S0026-4733.16.07192-3. Epub 2016 Nov 9.
To evaluate antimicrobial properties of Dermacyn in abdominal infections, and to develop a new method for peritoneal lavage without using antibiotics.
One hundred and ten patients suffering from intestinal perforation (abdominal closed injury), who had been treated with opened surgical repair or partial intestinal resection, were enrolled in this study. In the study group, Dermacyn was used for peritoneal lavage. During the same period, 102 patients with intestinal perforation of abdominal closed injury and opened repair or partial intestinal resection were enrolled as a control group. For the control group, metronidazole physiological saline was used for peritoneal lavage. Patients from both groups had a postoperative indwelling peritoneal drainage tube. Five objective indicators were studied and compared at 24, 48, and 72 hours: volume of drainage, drainage fluid culture, blood routine test, C-reactive protein, calcitonin and antibiotics dose.
There were no significant differences between the drainage volumes in two groups three days after the operation. There were significant differences in the nature of the drainage fluid, bacterial culture results, blood routine, C-reactive protein and procalcitonin between the two groups. In the experimental group, after the Dermacyn flushing, the average volume of peritoneal drainage fluid was reduced (from 30 to 5 mL) from 24 to 72 hours postoperatively.
The use of Dermacyn as an antibiotic agent for intraoperative peritoneal lavage was effective in reducing the risk of infection, due to its broad-spectrum bactericidal effect. Dermacyn could be used safely to perform peritoneal flushing to clean the operation site.
评估 Dermacyn 在腹部感染中的抗菌特性，并开发一种不使用抗生素的腹腔灌洗新方法。
110 例因肠穿孔（腹部闭合性损伤）接受开放手术修复或部分肠切除治疗的患者纳入本研究。研究组使用 Dermacyn 进行腹腔灌洗。同期，102 例腹部闭合性损伤肠穿孔并接受开放修复或部分肠切除的患者作为对照组。对照组使用甲硝唑生理盐水进行腹腔灌洗。两组患者术后均留置腹腔引流管。在术后 24、48 和 72 小时研究并比较五项客观指标：引流量、引流液培养、血常规、C 反应蛋白、降钙素和抗生素剂量。
术后三天两组引流量无显著差异。两组引流液性质、细菌培养结果、血常规、C 反应蛋白和降钙素存在显著差异。在实验组，Dermacyn 冲洗后，术后 24 至 72 小时腹腔引流液平均量减少（从 30 毫升降至 5 毫升）。
由于 Dermacyn 具有广谱杀菌作用，术中使用其作为抗生素进行腹腔灌洗可有效降低感染风险。Dermacyn 可安全用于腹腔冲洗以清洁手术部位。
