Mocarzel Luis Otávio, Bicca Jessica, Jarske Luiza, Oliveira Thamires, Lanzieri Pedro, Gismondi Ronaldo, Ribeiro Mario Luiz
Department of Internal Medicine, Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, Brazil.
Department of Cardiology, Hospital Universitário Antônio Pedro (HUAP), Niterói, Brazil.
Case Rep Gastroenterol. 2016 Oct 10;10(3):531-537. doi: 10.1159/000448885. eCollection 2016 Sep-Dec.
Hepatorenal syndrome (HRS) is defined as a failure of renal function, potentially reversible, in patients with liver cirrhosis and ascites. Recently, a component of cardiomyopathy associated with HRS was described, but the use of positive inotropic medicine as part of the treatment of the acute phase has not been extensively evaluated. We report a second case in our hospital of a patient with HRS type I without previous heart disease, with secondary hemodynamic decompensation due to liver disease, in which the abnormalities in systolic function by speckle-tracking echocardiography were observed and could be reversed by the use of inotropes. After partial response to current therapies, the patient presented a clinical and laboratorial response with improvement of renal function after infusion of dobutamine. Clinical studies are needed for the therapy approach to HRS taking into account myocardial dysfunction as a major contributing factor for renal dysfunction.
肝肾综合征(HRS)被定义为肝硬化腹水患者出现的潜在可逆性肾功能衰竭。最近,有人描述了与HRS相关的心肌病成分,但正性肌力药物作为急性期治疗的一部分尚未得到广泛评估。我们报告我院第二例I型HRS患者,该患者既往无心脏病史,因肝病继发血流动力学失代偿,经斑点追踪超声心动图观察到收缩功能异常,使用正性肌力药物后可逆转。在对当前治疗部分有效后,患者在输注多巴酚丁胺后出现临床和实验室反应,肾功能得到改善。考虑到心肌功能障碍是肾功能障碍的主要促成因素,需要开展关于HRS治疗方法的临床研究。