Modak Atanu, Mondal Anirban, Watile Rahul, Mukherjee Semanti, Maiti Debabrata
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Chem Commun (Camb). 2016 Nov 24;52(96):13916-13919. doi: 10.1039/c6cc08302a.
This discovery illustrates selective meta C-H bond activation from multiple non-equivalent C-H bonds present in medicinally relevant arylethanesulfonic acid and the 2-arylpropanoic acid moiety using weakly coordinating nitrile as a directing group. Transformation of the meta olefinated compounds to important organic molecules has been demonstrated. Efforts were made to obtain mechanistic detail of the meta C-H bond functionalization reaction.
这一发现表明，利用弱配位腈作为导向基团，可从药用相关芳基乙烷磺酸和2-芳基丙酸部分中存在的多个非等效C-H键中选择性地实现间位C-H键活化。已证明间位烯烃化化合物可转化为重要的有机分子。人们致力于获取间位C-H键官能化反应的机理细节。
