Liu Qian, Wu Jing, Shen Wen, Wei Ran, Jiang Jianhui, Liang Jinqun, Chen Min, Zhong Mei, Yin Aihua
a Department of Obstetrics and Gynecology , Southern Medical University, Nan fang Hospital , Guangzhou , China.
b Department of Medical Genetics Center , Guangdong Women and Children Hospital , Guangzhou , China.
J Matern Fetal Neonatal Med. 2017 Nov;30(22):2697-2704. doi: 10.1080/14767058.2016.1261395. Epub 2017 Mar 3.
To analyze the amino acids (AA) and acyl carnitine (AC) profiles in dry blood spot (DBS) specimens of low birth weight (LBW), preterm birth (PTB), and small for gestational age (SGA), and to compare the concentration difference of AA and AC with those without above.
This is a retrospectively study. Eight thousand nine hundred and seventy-nine uncomplicated pregnant newborns were enrolled into the study. DBS were collected on the third day of life, and concentrations of 11 types of AA, free carnitine and 30 types of AC were detected by using high-performance liquid chromatography tandem mass spectrometry (HPLC-MS). Shapiro-Wilk test and Kruskal-Wallis rank test were applied in statistical analysis.
Concentrations of most AA and AC in infants born in SGA were significantly higher than those in non-SGA group, while lower in LBW and PTB groups than those in non-LBW and non-PTB groups (p < 0.05).
The difference of concentration of AA and AC in the subgroups suggested there may be a dysutilization of AA and AC in SGA, but an inborn insufficient of AA and AC in LBW and PTB neonates.
分析低出生体重（LBW）、早产（PTB）和小于胎龄儿（SGA）干血斑（DBS）标本中的氨基酸（AA）和酰基肉碱（AC）谱，并比较AA和AC与无上述情况者的浓度差异。
这是一项回顾性研究。8979例无并发症的孕产新生儿纳入研究。在出生后第3天采集DBS，采用高效液相色谱串联质谱法（HPLC-MS）检测11种AA、游离肉碱和30种AC的浓度。统计分析采用Shapiro-Wilk检验和Kruskal-Wallis秩和检验。
SGA出生的婴儿中大多数AA和AC的浓度显著高于非SGA组，而LBW和PTB组低于非LBW和非PTB组（p < 0.05）。
亚组中AA和AC浓度的差异表明，SGA中可能存在AA和AC利用障碍，而LBW和PTB新生儿存在AA和AC先天性不足。
