Diaz J, Molgó J, Pécot-Dechavassine M
Département de Cytologie, Université Pierre et Marie Curie, Paris, France.
Neurosci Lett. 1989 Jan 16;96(2):127-32. doi: 10.1016/0304-3940(89)90045-1.
A single sublethal injection of botulinum type A toxin (BoTx-A) to winter frogs induced a general and complete paralysis of skeletal muscles, which lasted several months. Quantitative analysis of 483 end-plates from 8 BoTx-A poisoned muscles and 495 endplates from 8 control muscles revealed a higher and significant incidence of terminal and ultraterminal sprouts in poisoned junctions when taking into account the normal remodelling of motor innervation. We conclude that prolonged neuromuscular blockade by BoTx-A results in the extension of the nerve terminal arborization.
对冬季青蛙单次注射亚致死剂量的A型肉毒杆菌毒素（BoTx-A）会导致骨骼肌普遍且完全麻痹，这种麻痹持续数月。对8块注射BoTx-A的中毒肌肉中的483个终板和8块对照肌肉中的495个终板进行定量分析发现，考虑到运动神经支配的正常重塑，中毒连接处的终末和超终末芽生发生率更高且具有显著性。我们得出结论，BoTx-A导致的长时间神经肌肉阻滞会导致神经末梢分支延伸。
