甲状腺乳头状癌滤泡亚型和具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤（NIFTP）。

The follicular variant of papillary thyroid cancer and noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).

作者信息

Scharpf Joseph, Kamani Dipti, Sadow Peter M, Randolph Gregory W

机构信息

aDepartment of Otolaryngology, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio bDivision of Thyroid and Parathyroid Surgery, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary cDepartment of Pathology, Massachusetts General Hospital dDivision of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Curr Opin Oncol. 2017 Jan;29(1):20-24. doi: 10.1097/CCO.0000000000000341.

DOI:10.1097/CCO.0000000000000341

PMID:27845971

Abstract

PURPOSE OF REVIEW

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a new terminology proposed for encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC). Recently, thyroid cancer incidence has increased dramatically, without affecting related mortality rate. This increase is widely attributed to the intensified surveillance leading to a substantial increase in the diagnosis of small classic papillary thyroid cancers and EFVPTCs. Recent studies emphasize the indolent behavior of the EFVPTC. Recently, there has been a reclassification of EFVPTC as NIFTP, a benign entity. The financial and emotional burden of 'cancer' diagnosis and treatment can be significant.

RECENT FINDINGS

This review recapitulates the literature supporting the reclassification of EFVPTC as NIFTP, a benign entity, and reviews standardized diagnostic criteria for EFVPTC.

SUMMARY

The information highlighted in this review will affect surgical decision making and may promote the offering of hemithyroidectomy over a total thyroidectomy to some patients with 'indeterminate' cytopathological category; postoperative radioiodine ablation will not be required for NIFTP patients.

摘要

综述目的

具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤（NIFTP）是为甲状腺乳头状癌滤泡变异型（EFVPTC）提出的新术语。近年来，甲状腺癌发病率急剧上升，但相关死亡率并未受到影响。这种上升广泛归因于监测的加强，导致小的经典甲状腺乳头状癌和EFVPTC的诊断大幅增加。近期研究强调了EFVPTC的惰性生物学行为。最近，EFVPTC被重新分类为NIFTP，一种良性病变。“癌症”诊断和治疗带来的经济和情感负担可能很大。