Zhu Qiquan, Luo Xu, Zhang Jie, Liu Yun, Luo Hansheng, Huang Qin, Cheng Yuan, Xie Zongyi
Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Curr Drug Deliv. 2017 Sep 6;14(6):766-772. doi: 10.2174/1567201814666161116162148.
Ischemic stroke is the third leading cause of death and the most frequent cause of permanent disability in adults worldwide. Tremendous advances have been made in understanding of the pathophysiology of cerebral ischemia. Nevertheless, there is still no effective neuroprotectant available in the clinical work. Recently, osteopontin (OPN), a glycophosphoprotein, has attracted more attention due to its various effects in cardiovascular and nervous system diseases.
The aim of present review was to summarize recent findings about neuroprotective effects of OPN on ischemic stroke, targeting to provide a novel therapeutic strategy.
To prepare this review, a pathophysiological and pharmacological literature survey was performed using PubMed, and Web of Science. Also, some statistical and epidemiological literature sources were used.
Mounting evidence indicates that OPN attenuates cerebral damage and promotes neurogenesis in ischemic stroke by binding to its receptors to activate diverse signaling pathways.
The paper highlights the neuroprotective and pro-regenerative effects of OPN after cerebral ischemia, which would demonstrate its therapeutic potential in ischemic stroke and other informs of ischemic brain injury.
缺血性中风是全球成年人中第三大死亡原因，也是永久性残疾的最常见原因。在脑缺血病理生理学的理解方面已经取得了巨大进展。然而，临床工作中仍然没有有效的神经保护剂。最近，骨桥蛋白（OPN），一种糖磷蛋白，因其在心血管和神经系统疾病中的多种作用而受到更多关注。
本综述的目的是总结关于OPN对缺血性中风神经保护作用的最新发现，旨在提供一种新的治疗策略。
为撰写本综述，使用PubMed和科学网进行了病理生理学和药理学文献调查。还使用了一些统计和流行病学文献来源。
越来越多的证据表明，OPN通过与其受体结合激活多种信号通路，减轻缺血性中风中的脑损伤并促进神经发生。
本文强调了OPN在脑缺血后的神经保护和促再生作用，这将证明其在缺血性中风和其他形式的缺血性脑损伤中的治疗潜力。
