Ishimura J, Kawanaka M, Fukuchi M
Department of Nuclear Medicine, Hyogo College of Medicine, Japan.
Clin Nucl Med. 1989 Apr;14(4):278-81. doi: 10.1097/00003072-198904000-00009.
Forty-one patients with or without adrenocortical disorders were studied to evaluate the clinical usefulness of SPECT in adrenal imaging with I-131 Adosterol. In the SPECT images from this study, all glands with either normally functioning or hyperfunctioning adrenal cortices could be detected, while those glands with hypofunctioning adrenal cortices could not be detected. Particularly in transaxial and sagittal slices, the adrenal gland was identified posteriorly and was clearly distinguished from the gallbladder. In preliminary results using SPECT by a standard method, uptake in 68 detectable glands ranged from 1.7% to 4.9% in four glands with Cushing's syndrome, from 1.1% to 1.3% in seven glands with primary aldosteronism, and were distributed below 1.0% in the remaining glands with normally functioning adrenal cortices. These data show that it is possible to evaluate the adrenocortical functioning status simply by analyzing the SPECT images of the adrenal.
对41例患有或未患有肾上腺皮质疾病的患者进行了研究，以评估单光子发射计算机断层扫描（SPECT）在使用碘-131胆固醇进行肾上腺成像中的临床实用性。在本研究的SPECT图像中，所有肾上腺皮质功能正常或亢进的腺体均可被检测到，而肾上腺皮质功能减退的腺体则无法被检测到。特别是在横轴位和矢状位切片中，肾上腺位于后方，可与胆囊清晰区分。在使用标准方法进行SPECT的初步结果中，68个可检测到的腺体的摄取率在4例库欣综合征患者的4个腺体中为1.7%至4.9%，在7例原发性醛固酮增多症患者的7个腺体中为1.1%至1.3%，其余肾上腺皮质功能正常的腺体摄取率分布在1.0%以下。这些数据表明，仅通过分析肾上腺的SPECT图像就可以评估肾上腺皮质的功能状态。
