Lack of differentiation of the isolated murine statoacoustic ganglion during organ culture.

The isolated 12th gestational day statoacoustic ganglion (SAG) of the CBA/CBA mouse was cultured in vitro for 4-8 days. After 4 days, 25% of the SAG had survived, having nerve fibers growing in a circular pattern around the SAG. A further separation into a vestibular and a cochlear part, which occurs in vivo, was not observed. It is concluded that a trophic interaction between the SAG and target tissues is needed for further differentiation of the SAG.