Banka R, Udwadia Z
Department of Pulmonary Medicine, P. D. Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
J Postgrad Med. 2017 Jan-Mar;63(1):55-57. doi: 10.4103/0022-3859.194227.
Imatinib is a tyrosine kinase inhibitor and has rarely been reported to cause pleural effusion. We report the case of an 88-year-old male, known case of gastrointestinal stromal tumor on treatment with imatinib, who presented with a 2-week history of cough and dyspnea. He was diagnosed to have a right-sided pleural effusion and thoracentesis of the fluid revealed an exudate with low adenosine deaminase and negative cytology. Withdrawal of the drug lead to resolution of symptoms. We report this case to highlight the side effect profile of imatinib and warn physicians regarding this potential adverse effect which may be mistaken for metastasis or infection.
伊马替尼是一种酪氨酸激酶抑制剂，很少有报道称其会引起胸腔积液。我们报告一例88岁男性病例，该患者为已知的胃肠道间质瘤病例，正在接受伊马替尼治疗，出现咳嗽和呼吸困难2周病史。他被诊断为右侧胸腔积液，胸腔穿刺抽出的液体显示为渗出液，腺苷脱氨酶水平低且细胞学检查为阴性。停用该药物后症状缓解。我们报告此病例以突出伊马替尼的副作用特征，并提醒医生注意这种可能被误诊为转移或感染的潜在不良反应。
