Iida Yuko, Takano Yuki, Ishiwatari Yusaku, Yoshida Akiko, Shimizu Tetsuo, Ito Reiko, Hattori Tomohiro, Takahashi Noriaki, Hashimoto Shu
Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Japan.
Intern Med. 2016;55(22):3321-3323. doi: 10.2169/internalmedicine.55.6986. Epub 2016 Nov 15.
We herein describe the first known case of diffuse alveolar hemorrhage (DAH) associated with the administration of Makyo-kanseki-to, a Chinese herbal drug. A 64-year-old man with bronchial asthma presented with persistent cough. Makyo-kanseki-to was prescribed as an adjunctive treatment for bronchial asthma. Immediately after drug ingestion, the patient expectorated bloody sputum. DAH was diagnosed based on the presence of bilateral ground-glass opacity which was identified on chest computed tomography and bloody bronchoalveolar lavage fluid. We diagnosed that the administration of Makyo-kanseki-to was the responsible medication because the hemorrhage developed immediately after drug ingestion and resolved after the cessation of such medication with no subsequent recurrence.
我们在此描述首例已知的与服用中药麻子甘石汤相关的弥漫性肺泡出血（DAH）病例。一名64岁的支气管哮喘男性患者出现持续咳嗽。麻子甘石汤被用作支气管哮喘的辅助治疗药物。服药后不久，患者咳出带血痰液。根据胸部计算机断层扫描发现的双侧磨玻璃影以及血性支气管肺泡灌洗液，诊断为弥漫性肺泡出血。我们诊断服用麻子甘石汤是致病药物，因为出血在服药后立即出现，停药后出血缓解且未再复发。
