Guzelbey Tevfik, Gurses Bengi, Ozturk Erman, Ozveren Olcay, Sarsilmaz Aysegul, Karasu Ebru
Department of Radiology, School of Medicine, Yeditepe University, Istanbul, Turkey.
Department of Radiology, School of Medicine, Koc University, Istanbul, Turkey.
Iran J Radiol. 2016 May 10;13(3):e36375. doi: 10.5812/iranjradiol.36375. eCollection 2016 Jul.
Beta-thalassemia major (β-TM) patients need blood transfusions, which result in iron deposition. To regulate chelation therapy, iron load has to be measured. With MRI, the amount of signal loss and T2* decay time shortening are used for iron quantification.
The aim was to measure adrenal iron load with T2* relaxometry using MRI, and to compare it with liver and cardiac iron and serum ferritin, and to find out whether adrenal iron could be predicted from those parameters.
Between October 2014 and March 2015, MRI was performed in 21 patients with β-TM, recieving blood transfusions and chelation therapy. The control group (n = 11) included healthy volunteers with no known history of adrenal, hematologic, chronic disease, and blood transfusion.
Among patients, there was no significant correlation between plasma ferritin and adrenal T2*. Significant difference was detected among T2* values of adrenals between the patient and control groups. There was no significant correlation between adrenal gland and liver T2* in β-TM patients, moderate correlation was detected between adrenal T2* and cardiac T2*.
Adrenal iron in β-TM can be reliably measured in 3 Tesla MRI. The results highlight the absence of correlation between adrenal iron deposition both with serum ferritin and hepatic iron.
重型β地中海贫血（β-TM）患者需要输血，这会导致铁沉积。为了规范螯合疗法，必须测量铁负荷。通过MRI，信号损失量和T2*衰减时间缩短用于铁定量。
目的是使用MRI的T2*弛豫测量法测量肾上腺铁负荷，并将其与肝脏和心脏铁以及血清铁蛋白进行比较，并找出是否可以从这些参数预测肾上腺铁。
2014年10月至2015年3月期间，对21例接受输血和螯合疗法的β-TM患者进行了MRI检查。对照组（n = 11）包括无肾上腺、血液学、慢性病和输血病史的健康志愿者。
在患者中，血浆铁蛋白与肾上腺T2之间无显著相关性。患者组和对照组肾上腺的T2值之间存在显著差异。β-TM患者肾上腺与肝脏T2之间无显著相关性，肾上腺T2与心脏T2*之间存在中度相关性。
在3特斯拉MRI中可以可靠地测量β-TM患者的肾上腺铁。结果突出了肾上腺铁沉积与血清铁蛋白和肝脏铁之间均无相关性。
