用合适的抗Thy-1.2单克隆抗体进行体内治疗可消除对Thy-1.1+病毒免疫效应T细胞的杂种抗性。
In vivo treatment with an appropriate anti-Thy-1.2 monoclonal antibody abrogates hybrid resistance to Thy-1.1+ virus-immune effector T cells.
作者信息
Doherty P C, Allan J E, Allan W
机构信息
Department of Experimental Pathology, John Curtin School of Medical Research, Canberra, Australia.
出版信息
Immunology. 1989 Apr;66(4):631-3.
The hybrid resistance (Hr) effect operates to limit the induction of T-cell-mediated inflammatory processes following transfer into recipients injected with murine lymphocytic choriomeningitis virus (LCMV). Adoptively transferred Thy-1.1+ H-2b (KbDb) LCM virus-immune T cells are inhibited in cyclophosphamide (Cy)-suppressed, virus-infected mice that are heterozygous for H-2Db (e.g. H-2k x b F1). Injection of recipient animals with monoclonal antibody (mAb) to Thy-1.2 resulted in the elimination of Thy-1.2+ H-2b x d F1 effectors on transfer to H-2b x d F1 recipients. The Hr effect was removed by mAb treatment of Thy-1.2+ F1 recipients given H-2b Thy-1.1+-immune T cells. Apparently Hr is mediated by a cell which is Thy-1+.
杂种抗性（Hr）效应在将其转移至注射了鼠淋巴细胞性脉络丛脑膜炎病毒（LCMV）的受体后，会限制T细胞介导的炎症过程的诱导。过继转移的Thy-1.1+H-2b（KbDb）LCM病毒免疫T细胞在环磷酰胺（Cy）抑制的、感染病毒的、H-2Db杂合的小鼠（例如H-2kxb F1）中受到抑制。给受体动物注射抗Thy-1.2单克隆抗体（mAb）会导致在将Thy-1.2+H-2bxd F1效应细胞转移至H-2bxd F1受体后，这些效应细胞被清除。通过对接受H-2b Thy-1.1+免疫T细胞的Thy-1.2+ F1受体进行mAb处理，可消除Hr效应。显然，Hr是由Thy-1+细胞介导的。
Zotero 插件