肠道黏膜在急性胃肠道移植物抗宿主病中的作用。
Role of the intestinal mucosa in acute gastrointestinal GVHD.
作者信息
Peled Jonathan U, Hanash Alan M, Jenq Robert R
机构信息
Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; and.
Weill Cornell Medical College, New York, NY.
出版信息
Blood. 2016 Nov 17;128(20):2395-2402. doi: 10.1182/blood-2016-06-716738.
Abstract
Intestinal graft-versus-host disease (GVHD) remains a significant obstacle to the success of allogeneic hematopoietic cell transplantation. The intestinal mucosa comprises the inner lining of the intestinal tract and maintains close proximity with commensal microbes that reside within the intestinal lumen. Recent advances have significantly improved our understanding of the interactions between the intestinal mucosa and the enteric microbiota. Changes in host mucosal tissue and commensals posttransplant have been actively investigated, and provocative insights into mucosal immunity and the enteric microbiota are now being translated into clinical trials of novel approaches for preventing and treating acute GVHD. In this review, we summarize recent findings related to aspects of the intestinal mucosa during acute GVHD.
摘要
肠道移植物抗宿主病（GVHD）仍然是异基因造血细胞移植成功的重大障碍。肠道黏膜构成肠道的内层，并与存在于肠腔内的共生微生物保持密切接触。最近的进展显著增进了我们对肠道黏膜与肠道微生物群之间相互作用的理解。移植后宿主黏膜组织和共生菌的变化已得到积极研究，对黏膜免疫和肠道微生物群的深刻见解目前正转化为预防和治疗急性GVHD新方法的临床试验。在本综述中，我们总结了与急性GVHD期间肠道黏膜各方面相关的最新研究结果。
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