El Shorbagy Hatem H, Elsayed Mostafa A, Kamal Naglaa M, Azab Ahmed A, Bassiouny Mohamed M, Ghoneim Ibrahim A
Department of Pediatric, Menoufia University, Al Minufya, Egypt.
Department of Pediatric, Benha University, Benha, Egypt.
J Pediatr Neurosci. 2016 Jul-Sep;11(3):175-181. doi: 10.4103/1817-1745.193364.
Children with intractable epilepsy have chronic dysfunction of the autonomic nervous system causing myocardial ischemia. Heart-type fatty acid-binding protein (H-FABP) is a sensitive biomarker for myocardial ischemia.
We aimed to evaluate serum levels of H-FABP during seizures compared to their interictal levels and healthy controls and changes in heart rate (HR) and HR variability (HRV) in epileptic children with intractable seizures.
We included 30 epileptic seizures in 25 children with intractable epilepsy and 30 matched controls. They were subjected to video-electroencephalography monitoring simultaneously with Holter electrocardiogram and measurement of H-FABP.
Mean serum levels of H-FABP were increased significantly in patients either in the ictal or interictal periods compared to that in the controls ( < 0.001 and P< 0.01, respectively). There is no significant difference in serum levels of the H-FABP in the ictal and interictal periods. The basal time domain measures of HRV were significantly lower in the patient group compared to the control group.
H-FABP might suggest a degree of myocardial ischemia in intractable epilepsy. HRV is impaired in patients with refractory seizures.
难治性癫痫患儿存在自主神经系统慢性功能障碍，可导致心肌缺血。心脏型脂肪酸结合蛋白（H-FABP）是心肌缺血的敏感生物标志物。
我们旨在评估癫痫发作期间与发作间期及健康对照相比的血清H-FABP水平，以及难治性癫痫患儿的心率（HR）和心率变异性（HRV）变化。
我们纳入了25名难治性癫痫患儿的30次癫痫发作以及30名匹配的对照。他们同时接受视频脑电图监测、动态心电图监测以及H-FABP测量。
与对照组相比，患者在发作期和发作间期的血清H-FABP平均水平均显著升高（分别为P<0.001和P<0.01）。发作期和发作间期的血清H-FABP水平无显著差异。与对照组相比，患者组HRV的基础时域测量值显著更低。
H-FABP可能提示难治性癫痫中心肌缺血的程度。难治性癫痫患者的HRV受损。
