探索血管周围间隙的功能：一种关于脑部疾病的统一理论。
Exploring the Virchow-Robin spaces function: A unified theory of brain diseases.
作者信息
Cherian Iype, Beltran Margarita, Kasper Ekkehard M, Bhattarai Binod, Munokami Sunil, Grasso Giovanni
机构信息
Department of Neurosurgery College of Medical Sciences, Bharatpur, Chitwan, Nepal.
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Surg Neurol Int. 2016 Oct 7;7(Suppl 26):S711-S714. doi: 10.4103/2152-7806.192486. eCollection 2016.
BACKGROUND
Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases.
METHODS
Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI).
RESULTS
In this study, we have outlined the possible role of VRS in different pathological conditions.
CONCLUSION
The new insights into the physiology of the CSF circulation may have important clinical relevance for understanding the mechanisms underlying brain pathologies and their cure.
背景
目前认为脑脊液（CSF）在中枢神经系统（CNS）中的运输并非遵循传统路径。促进脑脊液从脑基底池进入脑间质液（ISF）的血管周围间隙（VRS）在一系列全新的研究中受到关注。此外，新的证据表明VRS可能参与脑部疾病的不同病理机制。
方法
在此，我们综述了一些新出现的研究，这些研究证明了VRS在睡眠、阿尔茨海默病、慢性创伤性脑病和创伤性脑损伤（TBI）中的可能作用。
结果
在本研究中，我们概述了VRS在不同病理状况下的可能作用。
结论
对脑脊液循环生理学的新见解可能对理解脑部疾病的潜在机制及其治疗具有重要的临床意义。
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