Wang Yu, Jin Ying, Wang Yi-Yue, Xu Dan-Ni, Lin Xiao-Ping
Department of Stomatology, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China. E-mail:
Shanghai Kou Qiang Yi Xue. 2016 Aug;25(4):443-447.
To investigate the influence of IL-35 in the pathogenesis of periodontitis and oral lichen planus, and the correlation between periodontitis and oral lichen planus patients.
The gingival crevicular fluid（GCF） and serum were collected from patients with oral lichen planus (n=20), periodontitis (n=20), periodontitis and oral lichen planus (n=20) and healthy controls (n=12). The patients' basic information, probing depth, clinical attachment loss, gingival index, sulcus bleeding index were measured and collected. The expression of IL-35 in GCF and serum was detected by ELISA. SPSS19.0 software package was used for statistical analysis.
The concentration of IL-35 in patients with periodontitis and oral lichen planus was significantly higher than that of other groups(P<0.05). There was significantly positive correlation between IL-35 level and periodontal clinical parameters.
Periodontitis and oral lichen planus may increase the concentration of IL-35 both in serum and GCF. The expression of IL-35 was positively correlated with periodontitis and oral lichen planus.
探讨白细胞介素-35（IL-35）在牙周炎和口腔扁平苔藓发病机制中的作用，以及牙周炎与口腔扁平苔藓患者之间的相关性。
收集口腔扁平苔藓患者（n = 20）、牙周炎患者（n = 20）、牙周炎合并口腔扁平苔藓患者（n = 20）及健康对照者（n = 12）的龈沟液（GCF）和血清。测量并收集患者的基本信息、探诊深度、临床附着丧失、牙龈指数、龈沟出血指数。采用酶联免疫吸附测定（ELISA）法检测GCF和血清中IL-35的表达。使用SPSS19.0软件包进行统计分析。
牙周炎患者和口腔扁平苔藓患者血清及龈沟液中IL-35浓度显著高于其他组（P < 0.05）。IL-35水平与牙周临床参数之间存在显著正相关。
牙周炎和口腔扁平苔藓可能会增加血清和龈沟液中IL-35的浓度。IL-35的表达与牙周炎和口腔扁平苔藓呈正相关。
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