Liu Di-xin, Jin Ying, Lin Xiao-ping
Department of Stomatology, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China. E-mail:
Shanghai Kou Qiang Yi Xue. 2015 Aug;24(4):455-9.
To investigate the concentration of IL-35 in serum and gingival crevicular fluid (GCF) and the correlation between IL-35 and periodontal clinical parameters, and explore the possible role of IL-35 in chronic periodontitis (CP).
Twenty patients with moderate or severe chronic periodontitis were selected as experimental group and 20 healthy people were included as control group. The patients' baseline information, probing depth (PD) and clinical attachment level (CAL) were recorded. Their serum and GCF were collected and then the concentration of IL-35 in GCF and serum were detected by ELISA. SPSS19.0 software package was used for statistical analysis.
The concentration of IL-35 in GCF and serum of chronic periodontitis were significantly higher than the control group (P<0.001). There was significant negative correlation between IL-35 and clinical parameters.
Chronic periodontitis may increase the concentration of IL-35 in serum and GCF; IL-35 level is negatively correlated with periodontitis.
探讨血清和龈沟液（GCF）中白细胞介素-35（IL-35）的浓度以及IL-35与牙周临床参数之间的相关性，探讨IL-35在慢性牙周炎（CP）中的可能作用。
选取20例中重度慢性牙周炎患者作为实验组，纳入20例健康人作为对照组。记录患者的基线信息、探诊深度（PD）和临床附着水平（CAL）。采集他们的血清和龈沟液，然后用酶联免疫吸附测定法（ELISA）检测龈沟液和血清中IL-35的浓度。使用SPSS19.0软件包进行统计分析。
慢性牙周炎患者龈沟液和血清中IL-35的浓度显著高于对照组（P<0.001）。IL-35与临床参数之间存在显著负相关。
慢性牙周炎可能会增加血清和龈沟液中IL-35的浓度；IL-35水平与牙周炎呈负相关。
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