Bonfiglio Luca, Bocci Tommaso, Minichilli Fabrizio, Crecchi Alessandra, Barloscio Davide, Spina Donata Maria, Rossi Bruno, Sartucci Ferdinando
Department of Translational Research on New Technologies in Medicine and Surgery, School of Physical Medicine and Rehabilitation, University of Pisa, Pisa, Italy.
Department of Clinical and Experimental Medicine, Cisanello Neurology Unit, Pisa University Medical School, Pisa, Italy.
Restor Neurol Neurosci. 2017;35(1):11-24. doi: 10.3233/RNN-160636.
As well as obtaining confirmation of the magnocellular system involvement in developmental dyslexia (DD); the aim was primarily to search for a possible involvement of the parvocellular system; and, furthermore, to complete the assessment of the visual chromatic axis by also analysing the koniocellular system.
Visual evoked potentials (VEPs) in response to achromatic stimuli with low luminance contrast and low spatial frequency, and isoluminant red/green and blue/yellow stimuli with high spatial frequency were recorded in 10 dyslexic children and 10 age- and sex-matched, healthy subjects.
Dyslexic children showed delayed VEPs to both achromatic stimuli (magnocellular-dorsal stream) and isoluminant red/green and blue/yellow stimuli (parvocellular-ventral and koniocellular streams). To our knowledge, this is the first time that a dysfunction of colour vision has been brought to light in an objective way (i.e., by means of electrophysiological methods) in children with DD.
These results give rise to speculation concerning the need for a putative approach for promoting both learning how to read and/or improving existing reading skills of children with or at risk of DD. The working hypothesis would be to combine two integrated interventions in a single programme aimed at fostering the function of both the magnocellular and the parvocellular streams.
除了证实大细胞系统与发育性阅读障碍（DD）有关外，主要目的是探寻小细胞系统可能存在的关联；此外，通过分析侏儒细胞系统来完善对视觉色彩轴的评估。
记录了10名阅读障碍儿童以及10名年龄和性别匹配的健康受试者对低亮度对比度和低空间频率的消色差刺激，以及高空间频率的等亮度红/绿和蓝/黄刺激的视觉诱发电位（VEP）。
阅读障碍儿童对消色差刺激（大细胞-背侧通路）以及等亮度红/绿和蓝/黄刺激（小细胞-腹侧和侏儒细胞通路）的VEP均延迟。据我们所知，这是首次通过客观方法（即通过电生理方法）揭示DD儿童存在色觉功能障碍。
这些结果引发了对于是否需要一种假定方法的推测，该方法用于促进患有DD或有DD风险的儿童学习阅读和/或提高其现有阅读技能。可行的假设是在一个单一计划中结合两种综合干预措施，旨在促进大细胞和小细胞通路的功能。
