Johnson Nicholas E, Hung Man, Nasser Eriko, Hagerman Katharine A, Chen Wei, Ciafaloni Emma, Heatwole Chad R
Department of Neurology, The University of Utah, UT, USA.
Department of Orthopaedics, The University of Utah, UT, USA.
J Neuromuscul Dis. 2015 Oct 7;2(4):447-452. doi: 10.3233/JND-150095.
The rate of symptom progression during pregnancy in myotonic dystrophy (DM) is not currently known. Further, there is little data regarding the rate of pregnancy complications and neonatal outcomes in DM.
This study assesses symptom progression and complication rates during pregnancy in women with DM.
DM women completed surveys regarding their prior pregnancies. Participants identified complications during their pregnancies and completed the Myotonic Dystrophy Health Index-Short Form (MDHI-SF) to measure their disease burden and identify the severity of select symptoms six-months prior to, during, and six-months after their first pregnancy.
152 women with DM reported on 375 pregnancies. Among these pregnancies, there was a 32.5% miscarriage rate. Some complications were common including: pre-term labor (27.8%), pre-eclampsia (10.4%), and peripartum hemorrhage (13.9%). Participants' perception of their mobility and ability to perform activities, as measured by the MDHI-SF, worsened during pregnancy and did not recover during the post-partum period.
Miscarriage, maternal disease progression during pregnancy, and other pregnancy related complications may occur in DM. Women with DM should be counseled on these potential risks prior to considering pregnancy.
目前尚不清楚强直性肌营养不良（DM）患者孕期症状进展的速率。此外，关于DM患者妊娠并发症发生率及新生儿结局的数据也很少。
本研究评估DM女性患者孕期的症状进展情况及并发症发生率。
DM女性患者完成关于其既往妊娠情况的调查。参与者确认孕期并发症，并完成强直性肌营养不良健康指数简表（MDHI-SF），以衡量其疾病负担，并确定首次妊娠前6个月、孕期及产后6个月特定症状的严重程度。
152例DM女性患者报告了375次妊娠情况。在这些妊娠中，流产率为32.5%。一些并发症很常见，包括早产（27.8%）、先兆子痫（10.4%）和产后出血（13.9%）。根据MDHI-SF测量，参与者对自身活动能力和进行日常活动能力的感知在孕期恶化，且产后未恢复。
DM患者可能会出现流产、孕期母体疾病进展及其他与妊娠相关的并发症。在考虑妊娠前，应向DM女性患者告知这些潜在风险。
