Fleury-Feith J, Van Nhieu J T, Picard C, Escudier E, Bernaudin J F
Service d'histologie, Hôpital Henri Mondor, Creteil, France.
Chest. 1989 Jun;95(6):1198-201. doi: 10.1378/chest.95.6.1198.
Lower pulmonary tract cell populations collected by bronchoalveolar lavages (BAL) were evaluated in three groups of immunocompromised patients: HIV infected patients with Pneumocystis carinii (PC) pneumonitis (n = 22), or pneumonitis not related to PC (n = 29), and non-HIV-infected, immunocompromised patients with a PC pneumonitis (n = 18). In AIDS patients with PC pneumonitis, the cell populations were 59.3 +/- 4.5 percent alveolar macrophages (AM), 19.6 +/- 2.5 percent lymphocytes, 14.6 +/- 4.4 percent polymorphonuclear cells (PMN), and 10.3 +/- 3.6 percent eosinophils. In HIV-infected patients without PC pneumonitis, they were 76.5 +/- 3.3 percent AM, 13 +/- 2.1 percent lymphocytes, 9.2 +/- 0.3 percent PMN, and 0.6 +/- 0.2 percent eosinophils, and in non-HIV-infected, immunocompromised patients with PC pneumonitis, they were 43.9 +/- 5.7 percent AM, 30.2 +/- 4.3 percent lymphocytes, 20.4 +/- 4.7 percent PMN, and 0.9 +/- 0.4 percent eosinophils. The most striking finding was a marked BAL eosinophilia in AIDS patients with PC pneumonitis. The significance of this particular cellular pulmonary response to PC is not clear, and its consequences on the lung structures and/or PC require evaluation.
通过支气管肺泡灌洗（BAL）收集的下呼吸道细胞群在三组免疫功能低下的患者中进行了评估：患有卡氏肺孢子虫（PC）肺炎的HIV感染患者（n = 22）、与PC无关的肺炎患者（n = 29）以及患有PC肺炎的非HIV感染免疫功能低下患者（n = 18）。在患有PC肺炎的艾滋病患者中，细胞群包括59.3±4.5%的肺泡巨噬细胞（AM）、19.6±2.5%的淋巴细胞、14.6±4.4%的多形核细胞（PMN）和10.3±3.6%的嗜酸性粒细胞。在没有PC肺炎的HIV感染患者中，它们分别为76.5±3.3%的AM、13±2.1%的淋巴细胞、9.2±0.3%的PMN和0.6±0.2%的嗜酸性粒细胞，而在患有PC肺炎的非HIV感染免疫功能低下患者中，它们分别为43.9±5.7%的AM、30.2±4.3%的淋巴细胞、20.4±4.7%的PMN和0.9±0.4%的嗜酸性粒细胞。最显著的发现是患有PC肺炎的艾滋病患者BAL中嗜酸性粒细胞显著增多。这种对PC的特定细胞肺部反应的意义尚不清楚，其对肺结构和/或PC的影响需要评估。
