Morrison G C, Weschler C J, Bekö G
Missouri University of Science & Technology, Rolla, MO, USA.
EOHSI, Rutgers University, Piscataway, NJ, USA.
Indoor Air. 2017 May;27(3):642-649. doi: 10.1111/ina.12354. Epub 2016 Dec 9.
In this research, we extend a model of transdermal uptake of phthalates to include a layer of clothing. When compared with experimental results, this model better estimates dermal uptake of diethylphthalate and di-n-butylphthalate (DnBP) than a previous model. The model predictions are consistent with the observation that previously exposed clothing can increase dermal uptake over that observed in bare-skin participants for the same exposure air concentrations. The model predicts that dermal uptake from clothing of DnBP is a substantial fraction of total uptake from all sources of exposure. For compounds that have high dermal permeability coefficients, dermal uptake is increased for (i) thinner clothing, (ii) a narrower gap between clothing and skin, and (iii) longer time intervals between laundering and wearing. Enhanced dermal uptake is most pronounced for compounds with clothing-air partition coefficients between 10 and 10 . In the absence of direct measurements of cotton cloth-air partition coefficients, dermal exposure may be predicted using equilibrium data for compounds in equilibrium with cellulose and water, in combination with computational methods of predicting partition coefficients.
在本研究中，我们扩展了邻苯二甲酸酯经皮吸收模型，使其包含一层衣物。与实验结果相比，该模型比先前的模型能更好地估算邻苯二甲酸二乙酯和邻苯二甲酸二正丁酯（DnBP）的皮肤吸收情况。模型预测结果与以下观察结果一致：对于相同的暴露空气浓度，先前穿着过的衣物会使皮肤吸收量高于裸皮参与者的吸收量。该模型预测，DnBP从衣物中的皮肤吸收量占所有暴露源总吸收量的很大一部分。对于具有高皮肤渗透系数的化合物，当（i）衣物更薄、（ii）衣物与皮肤之间的间隙更窄以及（iii）洗涤与穿着之间的时间间隔更长时，皮肤吸收量会增加。对于衣物 - 空气分配系数在10至10之间的化合物，皮肤吸收增强最为明显。在缺乏棉布 - 空气分配系数直接测量值的情况下，可以结合预测分配系数的计算方法，使用与纤维素和水处于平衡状态的化合物的平衡数据来预测皮肤暴露情况。
