子宫内膜癌早期检测的新方法。
Novel approaches to early detection of endometrial cancer.
作者信息
Bagaria Madhu, Shields Emily, Bakkum-Gamez Jamie N
机构信息
aDepartment of Obstetrics and Gynecology, Mayo Clinic Health System, Austin bDepartment of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA.
出版信息
Curr Opin Obstet Gynecol. 2017 Feb;29(1):40-46. doi: 10.1097/GCO.0000000000000332.
PURPOSE OF REVIEW
Detection of endometrial cancer at an early stage leads to better oncologic outcomes. To date, a screening test for endometrial cancer does not exist.
RECENT FINDINGS
Evolving knowledge of molecular changes involved in endometrial cancer carcinogenesis paired with sensitive and high-throughput technological advancements are a promising combination that can be leveraged to detect tumor DNA and proteins. These molecular biomarkers can be identified in biospecimens collected via minimally invasive and noninvasive approaches. Exploiting lower genital tract secretions as a biospecimen also allows for patient self-sampling.
SUMMARY
Successful development of a screening test for endometrial cancer using self-collected lower genital tract biospecimens has the potential to increase accessibility to care and improve patient compliance.
综述目的
早期发现子宫内膜癌可带来更好的肿瘤学结局。迄今为止，尚无用于子宫内膜癌的筛查测试。
最新发现
对子宫内膜癌致癌过程中分子变化的认识不断发展，再加上灵敏且高通量的技术进步，这是一个很有前景的组合，可用于检测肿瘤DNA和蛋白质。这些分子生物标志物可在通过微创和非侵入性方法收集的生物标本中鉴定出来。将下生殖道分泌物作为生物标本加以利用，还能让患者自行采样。
总结
利用自行采集的下生殖道生物标本成功开发子宫内膜癌筛查测试，有可能提高医疗服务的可及性并改善患者的依从性。
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