Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.
Angew Chem Int Ed Engl. 2016 Dec 5;55(49):15297-15300. doi: 10.1002/anie.201608338. Epub 2016 Nov 9.
Magneto-plasmonic Janus vesicles (JVs) integrated with gold nanoparticles (AuNPs) and magnetic NPs (MNPs) were prepared asymmetrically in the membrane for in vivo cancer imaging. The hybrid JVs were produced by coassembling a mixture of hydrophobic MNPs, free amphiphilic block copolymers (BCPs), and AuNPs tethered with amphiphilic BCPs. Depending on the size and content of NPs, the JVs acquired spherical or hemispherical shapes. Among them, hemispherical JVs containing 50 nm AuNPs and 15 nm MNPs showed a strong absorption in the near-infrared (NIR) window and enhanced the transverse relaxation (T ) contrast effect, as a result of the ordering and dense packing of AuNPs and MNPs in the membrane. The magneto-plasmonic JVs were used as drug delivery vehicles, from which the release of a payload can be triggered by NIR light and the release rate can be modulated by a magnetic field. Moreover, the JVs were applied as imaging agents for in vivo bimodal photoacoustic (PA) and magnetic resonance (MR) imaging of tumors by intravenous injection. With an external magnetic field, the accumulation of the JVs in tumors was significantly increased, leading to a signal enhancement of approximately 2-3 times in the PA and MR imaging, compared with control groups without a magnetic field.
磁等离子体各向异性 Janus 囊泡（JVs）通过在膜内不对称地集成金纳米粒子（AuNPs）和磁性纳米粒子（MNPs），用于体内癌症成像。通过共组装疏水性 MNPs、游离两亲嵌段共聚物（BCPs）和与两亲性 BCP 键合的 AuNPs 的混合物来制备混合 JVs。根据 NPs 的尺寸和含量，JVs 呈现出球形或半球形。其中，含有 50nm AuNPs 和 15nm MNPs 的半球形 JVs 在近红外（NIR）窗口中表现出强吸收，并由于 AuNPs 和 MNPs 在膜中的有序和密集堆积而增强了横向弛豫（T）对比效应。磁等离子体 JVs 可用作药物输送载体，其中负载物的释放可以通过近红外光触发，并且释放速率可以通过磁场进行调节。此外，JVs 被用作体内双模态光声（PA）和磁共振（MR）成像的成像剂，通过静脉注射。在外磁场的作用下，JVs 在肿瘤中的积累显著增加，导致 PA 和 MR 成像的信号增强约 2-3 倍，与没有磁场的对照组相比。
