Huang Peng, Lin Jing, Li Wanwan, Rong Pengfei, Wang Zhe, Wang Shouju, Wang Xiaoping, Sun Xiaolian, Aronova Maria, Niu Gang, Leapman Richard D, Nie Zhihong, Chen Xiaoyuan
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA).
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 (USA).
Angew Chem Int Ed Engl. 2013 Dec 23;52(52):13958-13964. doi: 10.1002/anie.201308986. Epub 2013 Dec 6.
The hierarchical assembly of gold nanoparticles (GNPs) allows the localized surface plasmon resonance peaks to be engineered to the near-infrared (NIR) region for enhanced photothermal therapy (PTT). Herein we report a novel theranostic platform based on biodegradable plasmonic gold nanovesicles for photoacoustic (PA) imaging and PTT. The disulfide bond at the terminus of a PEG-b-PCL block-copolymer graft enables dense packing of GNPs during the assembly process and induces ultrastrong plasmonic coupling between adjacent GNPs. The strong NIR absorption induced by plasmon coupling and very high photothermal conversion efficiency (η=37%) enable simultaneous thermal/PA imaging and enhanced PTT efficacy with improved clearance of the dissociated particles after the completion of PTT. The assembly of various nanocrystals with tailored optical, magnetic, and electronic properties into vesicle architectures opens new possibilities for the construction of multifunctional biodegradable platforms for biomedical applications.
金纳米颗粒（GNP）的分层组装能够将局域表面等离子体共振峰设计到近红外（NIR）区域，以增强光热疗法（PTT）。在此，我们报告一种基于可生物降解等离子体金纳米囊泡的新型诊疗平台，用于光声（PA）成像和PTT。PEG-b-PCL嵌段共聚物接枝末端的二硫键在组装过程中使GNP能够紧密堆积，并诱导相邻GNP之间产生超强等离子体耦合。等离子体耦合诱导的强烈近红外吸收和非常高的光热转换效率（η=37%）使得能够同时进行热/PA成像，并在PTT完成后提高解离颗粒的清除率，从而增强PTT疗效。将具有定制光学、磁性和电子特性的各种纳米晶体组装成囊泡结构，为构建用于生物医学应用的多功能可生物降解平台开辟了新的可能性。
