Oner Zulal, Sagіr Kahraman Aysegul, Kose Evren, Oner Serkan, Kavaklі Ahmet, Cay Mahmut, Ozbag Davut
Department of Anatomy, Karabük University, Karabük, Turkey.
Department of Radiology, İnönü University, Malatya, Turkey.
Anat Rec (Hoboken). 2017 Mar;300(3):549-555. doi: 10.1002/ar.23514. Epub 2016 Nov 24.
The aim of this study was cerebrospinal fluid (CSF) flow quantification in the cerebral aqueduct using phase-contrast cine magnetic resonance ımaging (PCC-MRI) according to both sexes and three different age groups to obtain normative data. Seventy two volunteers with no cerebral pathology were included in this study. Subjects were divided into three age groups: 20-34 years, 35-49 years, and 50-65 years including equal gender groups. CSF flow's quantitatively evaluation was performed with images that were obtained by 1.5 T Magnetic Resonance (MR) unit from cerebral aqueduct level on the semi-axial plan. Between groups, peak velocity (cm sec ), average velocity (cm/s), forward volume (mL), reverse volume (mL), net forward volume (mL), and average flow over range (ml/min) values of current flowing through aqueduct and average aqueductal areas were compared. There were no statistically significant differences in CSF flow parameters among different age groups and between sexes (P > 0.05). There was a statistically significant difference in average cerebral aqueduct area between the age group of 50-65 years and the other age groups (P = 0.002). The average aqueductal area was higher in the age group of 50-65 years. Normal aqueductal CSF flow parameters evaluated with PCC-MRI don't show a significant difference by age and sex. We have achieved the lower and upper values of these parameters would be useful in future clinical studies. The size of aqueductal area may also be explained by atrophy-dependent ventricular system dilatation in the elderly. Anat Rec, 300:549-555, 2017. © 2016 Wiley Periodicals, Inc.
本研究的目的是使用相位对比电影磁共振成像（PCC-MRI），根据性别和三个不同年龄组对大脑导水管中的脑脊液（CSF）流量进行定量分析，以获取正常数据。本研究纳入了72名无脑部病变的志愿者。受试者被分为三个年龄组：20-34岁、35-49岁和50-65岁，每个年龄组中男女数量相等。通过1.5T磁共振（MR）设备在半轴平面上从大脑导水管水平获取图像，对脑脊液流量进行定量评估。比较了不同组之间流经导水管的电流的峰值速度（cm/sec）、平均速度（cm/s）、正向流量（mL）、反向流量（mL）、净正向流量（mL）以及平均流量范围（ml/min）值和平均导水管面积。不同年龄组之间以及不同性别之间的脑脊液流量参数均无统计学显著差异（P>0.05）。50-65岁年龄组与其他年龄组之间的平均大脑导水管面积存在统计学显著差异（P = 0.002）。50-65岁年龄组的平均导水管面积更大。通过PCC-MRI评估的正常导水管脑脊液流量参数在年龄和性别上没有显著差异。我们得出的这些参数的下限和上限值将对未来的临床研究有用。导水管面积的大小也可能由老年人中依赖萎缩的脑室系统扩张来解释。《解剖学记录》，300:549-555，2017年。©2016威利期刊公司。
