将系统药理学模型整合到药物计量学中的哲学框架。
A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics.
作者信息
Duffull S B
机构信息
Otago Pharmacometrics Group, School of Pharmacy, University of Otago, Dunedin, New Zealand.
出版信息
CPT Pharmacometrics Syst Pharmacol. 2016 Dec;5(12):649-655. doi: 10.1002/psp4.12148. Epub 2016 Nov 12.
The framework for systems pharmacology style models does not naturally sit with the usual scientific dogma of parsimony and falsifiability based on deductive reasoning. This does not invalidate the importance or need for overarching models based on pharmacology to describe and understand complicated biological systems. However, it does require some consideration on how systems pharmacology fits into the overall scientific approach.
系统药理学风格模型的框架与基于演绎推理的简约性和可证伪性这一常见科学教条并不天然契合。这并不否定基于药理学的总体模型对于描述和理解复杂生物系统的重要性或必要性。然而，这确实需要对系统药理学如何融入整体科学方法进行一些思考。
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