Volle Geoffroy, Fraison Jean-Baptiste, Gobert Delphine, Goulenok Tiphaine, Dhote Robin, Fain Olivier, Gonzalez-Chiappe Solange, Lhote François, Papo Thomas, Thuillier Aurélie, Rivière Sophie, Mahr Alfred
Hospital Saint-Louis, University Paris Diderot, Paris, France.
Hospital Saint-Louis, University Paris Diderot, Paris, and Hospital Jean Verdier, University Leonard de Vinci, Bondy, France.
Arthritis Care Res (Hoboken). 2017 Sep;69(9):1429-1436. doi: 10.1002/acr.23155.
The nature and impact of food and other external triggers in recurrences of Behçet's disease (BD)-related oral ulcers (OUs) remain unknown. This survey investigated dietary and nondietary triggers of BD-related OU recurrences.
Patients with BD who were followed in 7 French hospital departments completed a self-administered patient questionnaire. General and specific dietary triggering factors were sought in open questions. The questionnaire also included closed questions, notably to evaluate the effect of 6 general triggering situations and 24 selected foods. The results were expressed as number (percentage) of positive responses.
Among the 101 questionnaires distributed, 81 were usable. Among the 81 patients, 96% fulfilled the International Criteria for Behçet's Disease classification criteria, and 53% qualified their OU recurrences during the previous 12 months as very discomforting or discomforting. For the 6 general situations suggested, 50 patients (62%) declared ≥1 as a "sure" trigger of OU recurrences. In both open and closed questions, the most frequent triggers were fatigue/stress (37-47% of patients) and food (32-35%). Among the 24 suggested foods, nuts (48%), pineapple (42%), peanuts (32%), Emmental cheese (30%), almonds (23%), lemons (22%), and other cheeses (21%) were the most frequently reported. The corresponding open question gave consistent findings but with lower frequencies.
Most patients can identify triggers of recurring BD-related OUs, with fatigue/stress and food representing the most frequent triggers. The management of OU must consider such external factors. The histamine-rich or -liberating properties of the commonly cited OU-triggering foods suggest a hyperreactivity mechanism.
食物及其他外部诱发因素在白塞病（BD）相关口腔溃疡（OU）复发中的性质和影响尚不清楚。本调查研究了BD相关OU复发的饮食和非饮食诱发因素。
在法国7个医院科室接受随访的BD患者完成了一份自行填写的患者问卷。在开放式问题中寻找一般和特定的饮食诱发因素。问卷还包括封闭式问题，特别是用于评估6种一般诱发情况和24种选定食物的影响。结果以阳性反应的数量（百分比）表示。
在分发的101份问卷中，81份可用。在这81名患者中，96%符合白塞病国际分类标准，53%将其在过去12个月内的OU复发描述为非常不适或不适。对于所建议的6种一般情况，50名患者（62%）宣称≥1种为OU复发的“确定”诱发因素。在开放式和封闭式问题中，最常见的诱发因素是疲劳/压力（37-47%的患者）和食物（32-35%）。在所建议的24种食物中，坚果（48%）、菠萝（42%）、花生（32%）、埃曼塔尔奶酪（30%）、杏仁（23%）、柠檬（22%）和其他奶酪（21%）是报告频率最高的。相应的开放式问题给出了一致的结果，但频率较低。
大多数患者能够识别BD相关OU复发的诱发因素，疲劳/压力和食物是最常见的诱发因素。OU的管理必须考虑这些外部因素。常见的OU诱发食物中富含组胺或具有组胺释放特性，提示存在一种高反应性机制。
