Shenavandeh Saeedeh, Asis Marziye, Eftekhari Mohammad Hassan, Aflaki Elham, Abdollahifard Gholam Reza, Abnavi Marjan Anvar, Ahmadi Afsaneh
Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
J Med Life. 2020 Apr-Jun;13(2):164-169. doi: 10.25122/jml-2019-0153.
Behçet's disease is a systemic vasculitis. Mucocutaneous involvement is the most prominent finding, but triggering factors are not well-known. We decided to assess the beliefs of patients with Behçet's disease regarding the potential role of food, mucosal injury, menstruation, and stress in the appearance of symptoms. In this cross-sectional study, 60 patients with Behçet's disease who fulfilled the International Study Group criteria for Behçet's disease and referred to the outpatient Behçet's clinic of Motahari, affiliated to Shiraz University of Medical Sciences, were included. A questionnaire was designed by the research team consisting of the rheumatologist involved in the study, two dietitians, and a psychiatrist. The patients were interviewed face-to-face to fill in the questionnaire. The assessed variables were all food categories, menstruation, psychological stress, and oral mucosal injury as the potential triggers of symptoms onset. The most common foods reported as triggers for oral ulcers were eggplant (78.3%), melon (68.3%), walnut (68.2%), and cantaloupe (66.7%). Walnut was reported by three patients (5%) as the most common trigger for genital ulcers. Nervous tension (83%) and annoying arguments (45%) were the two most common psychological stress triggers for oral ulcers. Seven patients (11.7%) reported tooth brushing, as the trigger for oral ulcers. The irregular menstrual cycle was a trigger for oral ulcers in only two patients. Food items such as eggplant, walnut and melon were common self-reported triggers for mucocutaneous lesions in patients with Behçet's disease. Nervous tension and annoying arguments were also common psychological triggers for oral aphthous ulcers.
白塞病是一种全身性血管炎。黏膜皮肤受累是最突出的表现，但触发因素尚不明确。我们决定评估白塞病患者对于食物、黏膜损伤、月经和压力在症状出现中潜在作用的看法。在这项横断面研究中，纳入了60例符合白塞病国际研究组标准且转诊至设拉子医科大学附属莫塔哈里白塞病门诊的白塞病患者。研究团队由参与研究的风湿病学家、两名营养师和一名精神科医生组成，设计了一份问卷。对患者进行面对面访谈以填写问卷。评估的变量包括所有食物类别、月经、心理压力和口腔黏膜损伤，作为症状发作的潜在触发因素。被报告为口腔溃疡触发因素的最常见食物是茄子（78.3%）、甜瓜（68.3%）、核桃（68.2%）和哈密瓜（66.7%）。三名患者（5%）报告核桃是生殖器溃疡最常见的触发因素。紧张情绪（83%）和烦人的争吵（45%）是口腔溃疡最常见的两种心理压力触发因素。七名患者（11.7%）报告刷牙是口腔溃疡的触发因素。月经周期不规律仅在两名患者中被报告为口腔溃疡的触发因素。茄子、核桃和甜瓜等食物是白塞病患者自我报告的黏膜皮肤病变常见触发因素。紧张情绪和烦人的争吵也是口腔阿弗他溃疡常见的心理触发因素。
