Schöffel U, Zeller T, Lausen M, Ruf G, Farthmann E H
Department of Surgery, University of Freiburg, Federal Republic of Germany.
Am J Surg. 1989 Jun;157(6):567-72. doi: 10.1016/0002-9610(89)90701-0.
The inflammatory response which is similar in all forms of peritonitis was recorded by determining the levels of parameters shown to represent the activation state of plasmatic and cellular systems as well as the inhibitory capacity of the plasma. In a selected series of patients with different underlying diseases, blood sampling was started at the time of admission when the clinical finding of an acute abdomen led to emergency laparotomy. Depending upon the duration of the illness and the severity of the peritonitis, a significant increase in fibrinopeptide A and of C3a could be detected within a few hours, which was followed by an increase in the elastase alpha-1-proteinase inhibitor complex. Differences due to variable cause could not be found. There was a striking correlation between the preoperative values of these three parameters and the postoperative course of the patients. Additionally, there was a significant enhancement of an endothelial proliferation-inhibiting capacity in the serums of the lethal group, whereas endotoxin could only be detected in trace amounts in four patients with intraabdominal infection in the preoperative period.
通过测定一系列代表血浆和细胞系统激活状态以及血浆抑制能力的参数水平，记录了所有类型腹膜炎中相似的炎症反应。在一系列患有不同基础疾病的选定患者中，当急性腹痛的临床症状导致急诊剖腹手术时，在入院时开始采血。根据疾病持续时间和腹膜炎严重程度，在数小时内可检测到纤维蛋白肽A和C3a显著增加，随后弹性蛋白酶α1 - 蛋白酶抑制剂复合物增加。未发现因病因不同而产生的差异。这三个参数的术前值与患者术后病程之间存在显著相关性。此外，致死组血清中内皮细胞增殖抑制能力显著增强，而术前仅在4例腹腔内感染患者中检测到微量内毒素。
