Hörl W H, Riegel W, Schollmeyer P, Rautenberg W, Neumann S
Clin Nephrol. 1986 Jun;25(6):304-7.
Plasma C3a and C5a levels as well as plasma levels of granulocyte lactoferrin, granulocyte myeloperoxidase and granulocyte elastase in complex with alpha 1-proteinase inhibitor (E-alpha 1PI) were investigated in 10 patients (52.7 +/- 5.9 years) undergoing maintenance hemodialysis (39.4 +/- 12.4 months) with hollow fiber dialyzers made from polymethylmethacrylate. Plasma levels of lactoferrin increased from 166.5 +/- 28.5 to 712.5 +/- 165.9 ng/ml, myeloperoxidase from 59.0 +/- 15.3 to 210.5 +/- 33.9 ng/ml and E-alpha 1PI from 114.2 +/- 18.1 to 681.8 +/- 102.6 ng/ml during dialysis. In contrast, plasma C3a levels rose from 179.8 +/- 33.6 to maximal 276.2 +/- 45.4 ng/ml and C5a from 55.7 +/- 8.1 to maximal 101.1 +/- 14.8 ng/ml. Our data indicate that degranulation of granulocytes occurs during dialysis despite only little complement activation and mild initial granulocytopenia.
对10例（年龄52.7±5.9岁）使用由聚甲基丙烯酸甲酯制成的中空纤维透析器进行维持性血液透析（39.4±12.4个月）的患者，研究了血浆C3a和C5a水平以及与α1-蛋白酶抑制剂结合的粒细胞乳铁蛋白、粒细胞髓过氧化物酶和粒细胞弹性蛋白酶的血浆水平。透析期间，乳铁蛋白的血浆水平从166.5±28.5 ng/ml增至712.5±165.9 ng/ml，髓过氧化物酶从59.0±15.3 ng/ml增至210.5±33.9 ng/ml，E-α1PI从114.2±18.1 ng/ml增至681.8±102.6 ng/ml。相比之下，血浆C3a水平从179.8±33.6 ng/ml升至最高276.2±45.4 ng/ml，C5a从55.7±8.1 ng/ml升至最高101.1±14.8 ng/ml。我们的数据表明，尽管仅有轻微的补体激活和轻度的初始粒细胞减少，但透析期间粒细胞会发生脱颗粒。
