前列腺癌中的分子成像与精准医学

Molecular Imaging and Precision Medicine in Prostate Cancer.

作者信息

Ceci Francesco, Fiorentino Michelangelo, Castellucci Paolo, Fanti Stefano

机构信息

Service of Nuclear Medicine, S. Orsola-Malpighi University Hospital, University of Bologna, Via Massarenti 9, Bologna 40138, Italy.

Department of Pathology, S. Orsola-Malpighi University Hospital, University of Bologna, Via Massarenti 9, Bologna 40138, Italy.

出版信息

PET Clin. 2017 Jan;12(1):83-92. doi: 10.1016/j.cpet.2016.08.004. Epub 2016 Sep 9.

DOI:10.1016/j.cpet.2016.08.004

PMID:27863569

Abstract

The aim of the present review is to discuss about the role of new probes for molecular imaging in the evaluation of prostate cancer (PCa). This review focuses particularly on the role of new promising radiotracers for the molecular imaging with PET/computed tomography in the detection of PCa recurrence. The role of these new imaging techniques to guide lesion-target therapies and the potential application of these molecular probes as theranostics agents is discussed. Finally, the molecular mechanisms underlying resistance to castration in PCa and the maintenance of active androgen receptor are discussed.

摘要

本综述的目的是探讨新型分子成像探针在前列腺癌（PCa）评估中的作用。本综述特别关注新型有前景的放射性示踪剂在PET/计算机断层扫描分子成像检测PCa复发中的作用。讨论了这些新型成像技术在指导病灶靶向治疗中的作用以及这些分子探针作为治疗诊断剂的潜在应用。最后，讨论了PCa中去势抵抗的分子机制以及活性雄激素受体的维持。