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α-生育酚对阿霉素诱导的大鼠心脏毒性的影响。

Effect of alpha-tocopherol on the cardiotoxicity of adriamycin in the rat.

作者信息

Sonneveld P

出版信息

Cancer Treat Rep. 1978 Jul;62(7):1033-6.

PMID:278640
Abstract

Adriamycin (ADR)-induced cardiomyopathy was studied in a rat model by means of electrocardiograms (ECGs), light microscopy, and determination of heart weight. Pretreatment with D-alpha-tocopherol (alpha-T) 24 hours prior to a high dose of ADR diminishes cardiotoxic effects, as judged by ECG changes, decreases in heart weight, and histologic changes. The response of an acute myeloid leukemia in a rat model to ADR was not affected by this pretreatment. The results provide evidence that alpha-T might be used to improve the therapeutic index of ADR.

摘要

通过心电图（ECG）、光学显微镜检查以及心脏重量测定，在大鼠模型中研究了阿霉素（ADR）诱导的心肌病。在高剂量阿霉素给药前24小时用D-α-生育酚（α-T）进行预处理，根据心电图变化、心脏重量减轻和组织学变化判断，可减轻心脏毒性作用。这种预处理并未影响大鼠模型中急性髓性白血病对阿霉素的反应。结果表明，α-T可能用于提高阿霉素的治疗指数。

相似文献

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Effect of alpha-tocopherol on the cardiotoxicity of adriamycin in the rat.α-生育酚对阿霉素诱导的大鼠心脏毒性的影响。
Cancer Treat Rep. 1978 Jul;62(7):1033-6.
2
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Activity of d,l-alpha-tocopherol (vitamin E) against cardiotoxicity induced by doxorubicin and doxorubicin with cyclophosphamide in mice.消旋-α-生育酚（维生素E）对阿霉素及阿霉素与环磷酰胺联用诱导的小鼠心脏毒性的作用
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