Chung D C, Ko Y C, Pai H H
Gaoxiong Yi Xue Ke Xue Za Zhi. 1989 Feb;5(2):91-5.
In order to examine the prevalence and risk factors of muscular fibrotic contracture (MFC) among school children in Jia-Dong Township, Pingtung County, a prevalence survey combined case-control study was carried out from January to April, 1988. All the school children aged from 6 to 19 years old were first screened at schools and then referred to the Provincial Pingtung Hospital for confirmatory diagnosis based on the non-invasion criteria. A total of 83 MFC cases were identified including 79 gluteal fibrotic contracture (GFC) patients, 3 deltoid fibrotic contracture (DFC) patients, and 1 affected both GFC and DFC. The prevalence was significantly higher in males (17.3 per 1,000) than in females (10.5 per 1,000). The prevalence was found to increase with age after 6 years of age, peaked at the age group of 13-15 years, and decline thereafter. Most MFC cases clustered in both Wen-Fon and Yuan-Wen villages locate in the southern coast of Taiwan Island. Among 83 MFC patients, 65 were further interviewed to obtain information on the risk factors of MFC. A total of 65 healthy classmates one-to-one matched with MFC cases on aged, sex, and living villages were selected as the control group which was also interviewed. The case-control study showed a positive association between the frequency of injection and the MFC in a dose-response relationship. The injection site also correlated with the development of the GFC and DFC. It was reasoned that the injection might be the most important risk factor of MFC. Follow-up study of 65 operated MFC cases indicated a high percentage (89.2%) of hyperscar formation in the incision region.
为调查屏东县佳冬乡学童肌肉纤维化挛缩（MFC）的患病率及危险因素，于1988年1月至4月进行了一项患病率调查结合病例对照研究。所有6至19岁的学童首先在学校进行筛查，然后根据非侵入性标准转诊至屏东省立医院进行确诊。共确诊83例MFC病例，其中包括79例臀肌纤维化挛缩（GFC）患者、3例三角肌纤维化挛缩（DFC）患者，1例同时患有GFC和DFC。男性患病率（每1000人中有17.3例）显著高于女性（每1000人中有10.5例）。发现6岁以后患病率随年龄增加，在13 - 15岁年龄组达到峰值，此后下降。大多数MFC病例集中在位于台湾岛南岸的文丰村和源文村。在83例MFC患者中，对65例进一步进行访谈以获取MFC危险因素的信息。选择65名在年龄、性别和居住村庄与MFC病例一对一匹配的健康同学作为对照组并进行访谈。病例对照研究显示注射频率与MFC之间呈剂量反应关系的正相关。注射部位也与GFC和DFC的发生相关。据推测，注射可能是MFC最重要的危险因素。对65例接受手术的MFC病例的随访研究表明，切口区域瘢痕过度形成的比例很高（89.2%）。
