Ansar Ahmed S, Talal N
Department of Medicine, University of Texas Health Science Center, San Antonio.
Scand J Rheumatol. 1989;18(2):69-76. doi: 10.3109/03009748909099921.
It has now been recognized that there are complex interactions between the gonadal endocrine and the immune systems. The action of sex hormones on the immune system has important physiological and pathological consequences. The preponderance in women of autoimmune diseases in humans and in experimental animals has a basis in sex hormones. Hypoandrogenic/hyperestrogenic states are thought to contribute to the disease process. This article presents evidence for the action of sex hormones in various experimental animal models of autoimmune diseases and discusses several mechanisms of sex hormone action on the immune system. These mechanisms remain complex and it is to be hoped that the recent advances in immunology, endocrinology, pharmacology, and molecular biology will enable the description and clarification of these mechanisms of action.
现在已经认识到，性腺内分泌系统和免疫系统之间存在复杂的相互作用。性激素对免疫系统的作用具有重要的生理和病理后果。人类和实验动物中自身免疫性疾病女性居多与性激素有关。雄激素缺乏/雌激素过多状态被认为会促进疾病进程。本文提供了性激素在各种自身免疫性疾病实验动物模型中的作用证据，并讨论了性激素对免疫系统作用的几种机制。这些机制仍然很复杂，希望免疫学、内分泌学、药理学和分子生物学的最新进展能够描述和阐明这些作用机制。
