Paavonen T
Department of Pathology and Transplantation Laboratory, University of Helsinki, Finland.
Ann Med. 1994 Aug;26(4):255-8. doi: 10.3109/07853899409147900.
Females have stronger immune responses than males. Female predominance in autoimmune diseases in both experimental animals and in man is also established. Sex hormones and some other steroid hormones have been shown to exert immunoregulatory effects in both in vivo and in vitro situations. Important mechanisms of hormone action on lymphocytes have gradually been revealed. In this paper the most intriguing effects of steroid hormones on immune system and present data suggesting hormonal influence on the pathogenesis of autoimmune diseases are summarized.
女性的免疫反应比男性更强。在实验动物和人类中，自身免疫性疾病中女性占主导地位也已得到证实。性激素和其他一些类固醇激素已被证明在体内和体外情况下都能发挥免疫调节作用。激素作用于淋巴细胞的重要机制已逐渐被揭示。本文总结了类固醇激素对免疫系统最引人关注的影响以及表明激素对自身免疫性疾病发病机制有影响的现有数据。
