Klaas H S, Clémence A, Marion-Veyron R, Antonietti J-P, Alameda L, Golay P, Conus P
Swiss National Centre of Competence in Research LIVES, Life Course and Inequality Research Centre (LINES), Faculty of Social and Political Sciences, University of Lausanne,Switzerland.
Psychology Institute, Faculty of Social and Political Sciences, University of Lausanne,Lausanne,Switzerland.
Psychol Med. 2017 Mar;47(4):718-729. doi: 10.1017/S0033291716002506. Epub 2016 Nov 21.
Awareness of illness (insight) has been found to have contradictory effects for different functional outcomes after the early course of psychosis. Whereas it is related to psychotic symptom reduction and medication adherence, it is also associated with increased depressive symptoms. In this line, the specific effects of insight on the evolution of functioning over time have not been identified, and social indicators, such as socio-occupational functioning have barely been considered. Drawing from social identity theory we investigated the impact of insight on the development of psychosocial outcomes and the interactions of these variables over time.
The participants, 240 patients in early phase of psychosis from the Treatment and Early Intervention in Psychosis Program (TIPP) of the University Hospital of Lausanne, Switzerland, were assessed at eight time points over 3 years. Cross-lagged panel analyses and multilevel analyses were conducted on socio-occupational and general functioning [Social and Occupational Functioning Assessment Scale (SOFAS) and Global Assessment of Functioning (GAF)] with insight, time and depressive symptoms as independent variables.
Results from multilevel analyses point to an overall positive impact of insight on psychosocial functioning, which increases over time. Yet the cross-lagged panel analysis did not reveal a systematic positive and causal effect of insight on SOFAS and GAF scores. Depressive symptoms seem only to be relevant in the beginning of the treatment process.
Our results point to a complex process in which the positive impact of insight on psychosocial functioning increases over time, even when considering depressive symptoms. Future studies and treatment approaches should consider the procedural aspect of insight.
研究发现,自知力(对疾病的认识)在精神病早期病程后对不同功能结局具有矛盾的影响。一方面,它与精神病症状减轻和药物依从性有关;另一方面,它也与抑郁症状增加有关。在这方面,自知力对功能随时间演变的具体影响尚未明确,社会指标,如社会职业功能,几乎未被考虑。基于社会认同理论,我们研究了自知力对心理社会结局发展的影响以及这些变量随时间的相互作用。
来自瑞士洛桑大学医院精神病治疗与早期干预项目(TIPP)的240名处于精神病早期阶段的患者在3年中的8个时间点接受了评估。以自知力、时间和抑郁症状作为自变量,对社会职业功能和总体功能[社会和职业功能评估量表(SOFAS)和功能总体评估(GAF)]进行了交叉滞后面板分析和多层次分析。
多层次分析结果表明自知力对心理社会功能具有总体积极影响,且这种影响随时间增加。然而,交叉滞后面板分析并未揭示自知力对SOFAS和GAF分数有系统的积极因果效应。抑郁症状似乎仅在治疗过程开始时相关。
我们的结果表明这是一个复杂的过程,其中即使考虑到抑郁症状,自知力对心理社会功能的积极影响也会随时间增加。未来的研究和治疗方法应考虑自知力的过程方面。