Department of Endocrinology and Metabolism, Tungs' Taichung MetroHarbor Hospital, Taichung 435, Taiwan; Department of Information Management, Hsing Wu University, New Taipei City, Taiwan.
Department of Biomedical Informatics, Asia University, Taichung 413, Taiwan; Department of Computer Science and Information Engineering, National Central University, Chungli, Taiwan.
J Diabetes Res. 2016;2016:9027484. doi: 10.1155/2016/9027484. Epub 2016 Oct 27.
. Type 2 diabetes mellitus patients are known to have higher risk of developing dementia while aspirin use has been shown to prevent incident dementia. This study was conducted to evaluate the potential benefits of aspirin use on dementia in patients with type 2 diabetes mellitus and identify the appropriate dosage of aspirin that provides the most benefit. . A Taiwan nationwide, population-based retrospective 8-year study was employed to analyze the association between the use of aspirin and incidence of dementia including Alzheimer's disease and non-Alzheimer's dementia using multivariate Cox-proportional hazards regression model and adjusting for several potential confounders. . Regular aspirin use in mean daily dosage of within 40 mg was associated with a decreased risk of developing incident Alzheimer's dementia in patients with type 2 diabetes mellitus (adjusted HR of 0.51 with 95% CI of 0.27-0.97, value 0.041). . A mean daily dosage of aspirin use within 40 mg might decrease the risk of developing Alzheimer's disease in patients with type 2 diabetes mellitus.
2 型糖尿病患者发生痴呆的风险较高，而阿司匹林的使用已被证明可预防痴呆的发生。本研究旨在评估阿司匹林对 2 型糖尿病患者痴呆的潜在益处，并确定提供最大益处的阿司匹林的合适剂量。
本研究采用了台湾全国范围内的基于人群的回顾性 8 年研究，使用多变量 Cox 比例风险回归模型分析了阿司匹林的使用与包括阿尔茨海默病和非阿尔茨海默病痴呆在内的痴呆发病之间的关联，并调整了几个潜在的混杂因素。在平均日剂量为 40mg 以内的常规阿司匹林使用与 2 型糖尿病患者发生阿尔茨海默病痴呆的风险降低相关（调整后的 HR 为 0.51，95%CI 为 0.27-0.97，P 值为 0.041）。在平均日剂量为 40mg 以内的阿司匹林使用可能会降低 2 型糖尿病患者发生阿尔茨海默病的风险。
