Choi Sun Ah, Jee Hye Jin, Bormate Katrina Joy, Kim Yeonjae, Jung Yi-Sook
Graduate School of Global Pharmaceutical Industry and Clinical Pharmacy, Ajou University, Suwon 16499, Republic of Korea.
AI-Super convergence KIURI Translational Research Center, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Biomol Ther (Seoul). 2023 Nov 1;31(6):583-598. doi: 10.4062/biomolther.2023.115.
Dementia is a clinical syndrome characterized by progressive impairment of cognitive and functional abilities. As currently applied treatments for dementia can only delay the progression of dementia and cannot fundamentally cure it, much attention is being paid to reducing its incidence by preventing the associated risk factors. Cardiovascular and metabolic diseases are well-known risk factors for dementia, and many studies have attempted to prevent dementia by treating these risk factors. Growing evidence suggests that sex-based factors may play an important role in the pathogenesis of dementia. Therefore, a deeper understanding of the differences in the effects of drugs based on sex may help improve their effectiveness. In this study, we reviewed sex differences in the impact of therapeutics targeting risk factors for dementia, such as cardiovascular and metabolic diseases, to prevent the incidence and/or progression of dementia.
痴呆是一种以认知和功能能力进行性损害为特征的临床综合征。由于目前用于治疗痴呆的方法只能延缓痴呆的进展，而不能从根本上治愈它，因此人们非常关注通过预防相关风险因素来降低其发病率。心血管疾病和代谢性疾病是众所周知的痴呆风险因素，许多研究试图通过治疗这些风险因素来预防痴呆。越来越多的证据表明，基于性别的因素可能在痴呆的发病机制中起重要作用。因此，深入了解基于性别的药物疗效差异可能有助于提高其有效性。在本研究中，我们综述了针对痴呆风险因素（如心血管疾病和代谢性疾病）的治疗方法在预防痴呆发病率和/或进展方面的性别差异。
