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经皮肾镜取石术中未被察觉的恶性肿瘤:暗藏的隐患。

Unsuspected Malignancy During Percutaneous Nephrolithotomy: The Snake in the Grass.

作者信息

Wu Charlotte Q, Matulay Justin T, Gupta Mantu, Motamedinia Piruz

机构信息

Department of Urology, Yale University , New Haven, Connecticut.

Department of Urology, New York-Presbyterian Columbia University , New York, New York.

出版信息

J Endourol Case Rep. 2016 Nov 1;2(1):184-188. doi: 10.1089/cren.2016.0110. eCollection 2016.

DOI:10.1089/cren.2016.0110
PMID:27868095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5107659/
Abstract

Squamous cell carcinoma of the upper tract (SCC-UT) is a rare neoplasm that disproportionately affects patients with longstanding nephrolithiasis. Diagnosis is challenging and typically comes at late stages; as such, the prognosis is poor. The absence of a reliable diagnostic predictor for SCC highlights the need to keep the diagnosis in mind for at-risk patient populations. In this study, we describe a small case series of rapidly progressive SCC-UT incidentally discovered during percutaneous nephrolithotomy.

摘要

上尿路鳞状细胞癌(SCC-UT)是一种罕见的肿瘤,对长期患有肾结石的患者影响尤为严重。诊断具有挑战性,通常在疾病晚期才能确诊;因此,预后较差。缺乏可靠的SCC诊断预测指标凸显了对高危患者群体进行诊断时需牢记该疾病的必要性。在本研究中,我们描述了一系列在经皮肾镜取石术中偶然发现的快速进展性SCC-UT的小病例系列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e568/5107659/96f0dee26e1c/fig-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e568/5107659/f3afd3b650c1/fig-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e568/5107659/9e0fbbc0a4b9/fig-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e568/5107659/d53151870999/fig-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e568/5107659/fb2680751e9d/fig-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e568/5107659/96f0dee26e1c/fig-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e568/5107659/f3afd3b650c1/fig-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e568/5107659/9e0fbbc0a4b9/fig-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e568/5107659/d53151870999/fig-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e568/5107659/fb2680751e9d/fig-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e568/5107659/96f0dee26e1c/fig-5.jpg

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本文引用的文献

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Squamous cell carcinoma of the renal pelvis associated with kidney stones: radiologic imaging features with gross and histopathological correlation.肾盂鳞状细胞癌合并肾结石:影像学特征与大体及组织病理学对照
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Immunohistochemical profile to distinguish urothelial from squamous differentiation in carcinomas of urothelial tract.免疫组织化学特征可区分尿路上皮来源的癌中的尿路上皮分化与鳞状分化。
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Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues: a useful immunomarker for breast and urothelial carcinomas.
免疫组织化学评估 GATA3 在肿瘤和正常组织中的表达:用于乳腺癌和尿路上皮癌的有用免疫标志物。
Am J Clin Pathol. 2012 Jul;138(1):57-64. doi: 10.1309/AJCP5UAFMSA9ZQBZ.
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Squamous cell carcinoma of the renal pelvis.肾盂鳞状细胞癌。
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Incidentally detected squamous cell carcinoma of renal pelvis in patients with staghorn calculi: case series with review of the literature.鹿角形结石患者中偶然发现的肾盂鳞状细胞癌:病例系列并文献复习
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Kidney stones: a global picture of prevalence, incidence, and associated risk factors.肾结石:全球范围内的患病率、发病率及相关风险因素概述
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Squamous cell carcinoma of the renal pelvis and ureter: incidence, symptoms, treatment and outcome.肾盂和输尿管鳞状细胞癌:发病率、症状、治疗及预后
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Mod Pathol. 2006 Apr;19(4):494-503. doi: 10.1038/modpathol.3800559.
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Proteome profiling of bladder squamous cell carcinomas: identification of markers that define their degree of differentiation.膀胱鳞状细胞癌的蛋白质组分析:确定其分化程度的标志物
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