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荧光二维肽图揭示 CD47 作为用于分析肝细胞癌和胆管细胞癌组织的潜在生物标志物。

Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues.

机构信息

International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, the Second Military Medical University, Shanghai, 200433, P. R. China.

Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai, 200237, P. R. China.

出版信息

Adv Mater. 2017 Feb;29(5). doi: 10.1002/adma.201604253. Epub 2016 Nov 21.

DOI:10.1002/adma.201604253
PMID:27869342
Abstract

A 2D peptidosheet unravels CD47 as a potential biomarker to image hepatocarcinoma and cholangiocarcinoma cells and tissues. Supramolecular assembly between water-soluble 2D MoS and a peptide probe produces the 2D peptidosheet suited for the profiling of hepatocarcinoma and cholangiocarcinoma tissues over healthy tissues on clinical specimens.

摘要

二维肽片揭示 CD47 作为一种潜在的生物标志物，可用于成像肝癌和胆管癌细胞和组织。水溶性二维 MoS2 与肽探针之间的超分子组装产生了二维肽片，适用于在临床标本上对肝癌和胆管癌组织与健康组织进行分析。

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