Kalman Douglas, Harvey Philip D, Perez Ojalvo Sara, Komorowski James
QPS-Miami Research Associates, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Miller School of Medicine, University of Miami, Miami, FL 33143, USA.
Nutrients. 2016 Nov 18;8(11):736. doi: 10.3390/nu8110736.
Inositol-stabilized arginine silicate (ASI; Nitrosigine) has been validated to increase levels of arginine, silicon and nitric oxide production. To evaluate potential enhancement of mental focus and clarity, ASI (1500 mg/day) was tested in two double-blind placebo-controlled crossover (DBPC-X) studies using the Trail Making Test (TMT, Parts A and B). In the two studies, healthy males took ASI for 14 and 3 days, respectively. In the first study, after 14 days of dosing, TMT B time decreased significantly from baseline (28% improvement, = 0.045). In the second study evaluating shorter-term effects, TMT B time decreased significantly compared to placebo (33% improvement, = 0.024) in a 10-min period. After 3 days of dosing, TMT B time significantly decreased from baseline scores (35% improvement, < 0.001). These findings show that ASI significantly improved the ability to perform complex cognitive tests requiring mental flexibility, processing speed and executive functioning.
肌醇稳定化的硅酸精氨酸（ASI；Nitrosigine）已被证实可提高精氨酸、硅的水平并促进一氧化氮的生成。为评估其对精神专注力和清晰度的潜在增强作用，在两项双盲安慰剂对照交叉试验（DBPC-X）中，使用连线测验（TMT，A部分和B部分）对ASI（1500毫克/天）进行了测试。在这两项研究中，健康男性分别服用ASI 14天和3天。在第一项研究中，给药14天后，TMT B的完成时间较基线显著缩短（改善28%，P = 0.045）。在第二项评估短期效果的研究中，在10分钟内，与安慰剂相比，TMT B的完成时间显著缩短（改善33%，P = 0.024）。给药3天后，TMT B的完成时间较基线分数显著缩短（改善35%，P < 0.001）。这些发现表明，ASI显著提高了执行需要精神灵活性、处理速度和执行功能的复杂认知测试的能力。
