[杜兴氏肌营养不良症心肌病的201Tl心肌单光子发射计算机断层扫描的序列变化]

[Sequential changes of the cardiomyopathy in Duchenne muscular dystrophy by 201Tl myocardial SPECT].

作者信息

Ono S, Jinnouchi S, Hoshi H, Sugimoto S, Inoue K, Watanabe K

机构信息

Department of Radiology, Miyazaki Higashi Byoin National Sanatorium, Japan.

出版信息

Radioisotopes. 1989 Mar;38(3):130-5. doi: 10.3769/radioisotopes.38.3_130.

DOI:10.3769/radioisotopes.38.3_130

PMID:2787039

Abstract

201Tl myocardial SPECT was performed to evaluate cardiomyopathy in Duchenne type of progressive muscular dystrophy (DMD). Follow up SPECT images of the same patients were also obtained about 1 year after the first scan. Cases subjected to study were 10 DMD. At the first study the hypoperfusion area of the left ventricular muscle was observed in 6 cases (60%) out of 10. At the second study the hypoperfusion areas became wider and lower in 4 out of 6 cases (66.7%). The new hypoperfusion area which was not demonstrated at the first study was observed at the second study in one case of these cases. These results suggested that the positive rate of cardiomyopathy in DMD by 201Tl myocardial SPECT was high, and 201Tl myocardial SPECT is a useful examination to detect the change of myocardial damage in DMD.

摘要

进行201铊心肌单光子发射计算机断层扫描（SPECT）以评估杜氏进行性肌营养不良症（DMD）中的心肌病。在首次扫描约1年后，还获取了同一患者的随访SPECT图像。研究对象为10例DMD患者。在首次研究中，10例中有6例（60%）观察到左心室肌肉灌注不足区域。在第二次研究中，6例中有4例（66.7%）灌注不足区域变得更广泛且更低。在这些病例中的1例第二次研究中观察到了首次研究未显示的新灌注不足区域。这些结果表明，201铊心肌SPECT检测DMD中心肌病的阳性率很高，且201铊心肌SPECT是检测DMD中心肌损伤变化的有用检查方法。