Koss Wendy A, Frick Karyn M
Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
J Neurosci Res. 2017 Jan 2;95(1-2):539-562. doi: 10.1002/jnr.23864.
Sex differences in the function of the hippocampus have been observed in numerous mammalian species. However, the magnitude, extent, and specificity of these differences are unclear because they can depend on factors including age, methodology, and environment. This Review will discuss seminal studies examining sex differences in hippocampal memory, neuronal morphology, synaptic plasticity, and cell signaling in humans and rodents. We also describe possible organizational and activational effects of sex steroid hormones during early development, puberty, and adulthood that may lead to sex differences observed in the hippocampus. We conclude by discussing the implications of sex differences in hippocampal function for mental health. © 2016 Wiley Periodicals, Inc.
在众多哺乳动物物种中都观察到了海马体功能的性别差异。然而，这些差异的大小、程度和特异性尚不清楚，因为它们可能取决于年龄、方法和环境等因素。本综述将讨论关于人类和啮齿动物海马体记忆、神经元形态、突触可塑性和细胞信号传导方面性别差异的开创性研究。我们还描述了在早期发育、青春期和成年期，性类固醇激素可能产生的组织和激活作用，这些作用可能导致海马体中观察到的性别差异。最后，我们将讨论海马体功能性别差异对心理健康的影响。© 2016威利期刊公司
