Perez-Novo Claudina, Pezato Rogério
aDepartment Biomedical Sciences, University Antwerp; Laboratory of Proteinchemistry, Proteomics Epigenetic Signaling, Wilrijk, Belgium bDepartment of Otolaryngology, Head and Neck Surgery, ENT Research Laboratory, Federal University of São Paulo, São Paulo, Brazil.
Curr Opin Allergy Clin Immunol. 2017 Feb;17(1):1-4. doi: 10.1097/ACI.0000000000000328.
Two main pillars are implicated in nasal polyposis development: a severe imbalance in immunomodulation and a mechanical dysfunction because of an abnormal remodeling process. Dendritic cells play a crucial role in the link between innate and adaptive immune response and orchestrating the T-cell response and are implicated in the severe inflammatory process found in nasal polypoid tissue. This review summarizes the existent knowledge about dendritic cells in nasal polyposis.
Dendritic cells are found increased in nasal polyposis, regardless of subset. Of interest, plasmacytoid dendritic cells are decreased in patients with a more severe Th2 profile, suggesting an important role of the cytokines milieu in their functional response or that plasmacytoid dendritic cell could act mitigating the inflamed process found in polypoid tissue.
Understanding the dendritic cell subset expression in different environments, as well as the effect of these subsets on T-cell differentiation will greatly improve the development of new therapies in nasal polyposis.
