Yang Chang, Liu Tianbo, Xia Bairong, Gu Lina, Lou Ge
Department of Gynecology, Tumor Hospital of Harbin Medical University, Harbin, China.
Int J Gynecol Cancer. 2017 Jan;27(1):22-27. doi: 10.1097/IGC.0000000000000850.
This study aimed to reveal whether collagen triple helix repeat containing 1 (CTHRC1) was a predictor of peritoneal and lymph node metastases in epithelial ovarian cancer, which had not been researched by others previously.
Western blot analysis showed that dramatic overexpression of CTHRC1 could be seen in most metastatic tissues. Univariate and multivariate logistic regression analyses demonstrated that overexpression of CTHRC1 was linked with peritoneal dissemination and lymph node metastasis in epithelial ovarian cancer.
The negative and sensitivity-predictive values of CTHRC1 staining were excellent for both lymph node and peritoneal metastases. The odds ratio of high versus low staining for peritoneal dissemination was 2.250 (95% confidence interval, 1.126-4.496), and that for lymph node metastasis was 13.102 (95% confidence interval, 6.036-28.439).
Collagen triple helix repeat containing 1 may potentially be used as a predictive marker of clinical progression in ovarian cancer either alone or in combination with other markers.
本研究旨在揭示含胶原蛋白三螺旋重复序列1（CTHRC1）是否为上皮性卵巢癌腹膜和淋巴结转移的预测指标，此前尚无其他人对此进行过研究。
蛋白质免疫印迹分析显示，在大多数转移组织中可观察到CTHRC1显著过表达。单因素和多因素逻辑回归分析表明，CTHRC1过表达与上皮性卵巢癌的腹膜播散和淋巴结转移有关。
CTHRC1染色的阴性预测值和敏感度预测值对淋巴结转移和腹膜转移均表现出色。腹膜播散高染色与低染色的比值比为2.250（95%置信区间，1.126 - 4.496），淋巴结转移的比值比为13.102（95%置信区间，6.036 - 28.439）。
含胶原蛋白三螺旋重复序列1可能单独或与其他标志物联合用作卵巢癌临床进展的预测标志物。
