Ojamaa Kristiina, Veerus Piret, Baburin Aleksei, Everaus Hele, Innos Kaire
*Oncology Centre, East Tallinn Central Hospital, Tallinn; †Faculty of Medicine, Tartu University, Tartu; ‡Women's Clinic, West Tallinn Central Hospital; §Department of Epidemiology and Biostatistics, National Institute for Health Development, Tallinn; and ∥Haematology-Oncology Clinics, Tartu University Hospital, Tartu, Estonia.
Int J Gynecol Cancer. 2017 Jan;27(1):44-49. doi: 10.1097/IGC.0000000000000858.
The objective of the study was to examine temporal trends in ovarian cancer (OC) survival in Estonia during 1995 to 2009 in relation to age and stage.
Estonian Cancer Registry data on all adult cases of primary OC diagnosed during 1995 to 2009 and followed up for vital status until 2014 were used to estimate relative survival ratios (RSRs). Cohort analysis was used to estimate 1-, 2-, and 5-year RSRs for patients diagnosed in 1995 to 1999, 2000 to 2004, and 2005 to 2009. Analysis was performed by age at diagnosis (<50; 50-59; 60-69; 70+ years) and stage (International Federation of Gynecology and Obstetrics 1988).
Among 2296 women included in the study, the age-adjusted 5-year RSR improved from 27% in 1995 to 1999 to 38% in 2005 to 2009. Survival increase of 10% units from 1995 to 1999 to 2005 to 2009 was seen for women aged 50 to 59 and 60 to 69 years. Among younger and older women, the respective changes were smaller. In 1995 to 1999, the difference in survival between the youngest and oldest age groups was 41% units. This decreased over the study period to 37% units. From 1995 to 1999 to 2005 to 2009, the 5-year RSR increased from 82% to 91% for stage I patients; from 48% to 67% for stage II patients; from 25% to 35% for stage III patients; and from 11% to 16% for stage IV patients.
The study showed an improvement of OC survival in Estonia in all age and stage groups, but particularly among younger women and those with early stage disease. Slower progress among older women is of great concern.
本研究的目的是调查1995年至2009年爱沙尼亚卵巢癌（OC）患者的生存时间趋势，并分析其与年龄和分期的关系。
利用爱沙尼亚癌症登记处的数据，纳入1995年至2009年诊断的所有原发性OC成年病例，并随访至2014年的生命状态，以估计相对生存率（RSRs）。采用队列分析方法，对1995年至1999年、2000年至2004年和2005年至2009年诊断的患者估计1年、2年和5年的RSRs。分析按诊断时的年龄（<50岁；50 - 59岁；60 - 69岁；70岁及以上）和分期（国际妇产科联盟1988年分期）进行。
在纳入研究的2296名女性中，年龄调整后的5年RSR从1995年至1999年的27%提高到2005年至2009年的38%。50至59岁和60至69岁的女性从1995年至1999年到2005年至2009年生存率提高了10个百分点。在年轻和老年女性中，各自的变化较小。1995年至1999年，最年轻和最年长年龄组之间的生存差异为41个百分点。在研究期间，这一差异降至37个百分点。从1995年至1999年到2005年至2009年，I期患者的5年RSR从82%提高到91%；II期患者从48%提高到67%；III期患者从25%提高到35%；IV期患者从11%提高到16%。
该研究表明，爱沙尼亚所有年龄和分期组的OC生存率均有所提高，但年轻女性和早期疾病患者尤为明显。老年女性进展较慢令人高度关注。
