Martz E, Howell D M
Immunol Today. 1989 Mar;10(3):79-86. doi: 10.1016/0167-5699(89)90231-4.
It is usually presumed that cytotoxic T lymphocytes (CTL) stop viral replication by lysing infected cells before a full virus yield has been assembled. Unlike complement-mediated lysis, however, CTL induce apoptosis, including fragmentation of target cell DNA. Why should CTL do this? Here, Eric Martz and Donna Howell suggest that since the major function of CTL appears to be control of viruses, CTL may be able to halt viral replication without inducing rapid lysis. It may be more useful to think of CTL as virus control cells rather than as cytolytic cells.
通常认为，细胞毒性T淋巴细胞（CTL）在完整的病毒产生之前通过裂解被感染细胞来阻止病毒复制。然而，与补体介导的裂解不同，CTL诱导细胞凋亡，包括靶细胞DNA的片段化。CTL为什么要这样做呢？在这里，埃里克·马尔茨和唐娜·豪厄尔认为，由于CTL的主要功能似乎是控制病毒，CTL可能能够在不诱导快速裂解的情况下阻止病毒复制。将CTL视为病毒控制细胞而非细胞溶解细胞可能更有用。
